Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease

Abstract

Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation and progresses toward inflammation and fibrosis. Nuclear receptors (NRs), like the Peroxisome Proliferator-Activated Receptors alpha and gamma (PPARα and PPARy), the Farnesoid X Receptor (FXR), and the Liver X receptor (LXR), regulate genes by heterodimerizing with Retinoid X receptor (RXR). These receptors are emerging targets for pharmaceutical intervention for metabolic diseases.

Keywords: FXR; LXR; NAFLD; NASH; PPARalpha; PPARgamma; fibrosis; nuclear receptors.