Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF2α

Qiqi Fu; Jiali Yang; Hui Jiang; Shangfei Lin; Haokuan Qin; Jie Zhao; Yanqing Wang; Muqing Liu

doi:10.1002/jbio.202300448

Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF_2α

J Biophotonics. 2024 Feb 13:e202300448. doi: 10.1002/jbio.202300448. Online ahead of print.

Authors

Qiqi Fu¹, Jiali Yang¹, Hui Jiang², Shangfei Lin², Haokuan Qin², Jie Zhao¹, Yanqing Wang³, Muqing Liu^{1

4}

Affiliations

¹ School of Information Science and Technology, Fudan University, Shanghai, China.
² Academy for Engineering and Technology, Fudan University, Shanghai, China.
³ School of Basic Medical Science, Fudan University, Shanghai, China.
⁴ Zhongshan Fudan Joint Innovation Center, Zhongshan, Guangdong Province, China.

PMID: 38348528
DOI: 10.1002/jbio.202300448

Abstract

Photobiomodulation (PBM) has attracted widespread attention in suppressing various pain and inflammation. Primary dysmenorrhea (PD) primarily occurs in adolescents and adult females, and the limited effectiveness and side effects of conventional treatments have highlighted the urgent need to develop and identify new adjunct therapeutic strategies. In this work, the results of pain and PGs demonstrated that 850 nm, 630 nm, and 460 nm all exhibited pain inhibition, decreased PGF_2α and upregulated PGE₂ , while 630 nm PBM has better effectiveness. Then to explore the underlying biological mechanisms of red light PBM on PD, we irradiated prostaglandin-F_2α induced HUSM cells and found that low-level irradiance can restore intracellular calcium ion, ROS, ATP, and MMP levels to normal levels. And, red light enhanced cell viability and promoted cell proliferation for normal HUSM cells. Therefore, this study proposes that red light PBM may be a promising approach for the future clinical treatment of PD.

Keywords: Ca2+; ROS; cell viability; photobiomodulation; primary dysmenorrhea; prostaglandins.

Abstract

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