Advances in the study of the correlation between insulin resistance and infertility

Front Endocrinol (Lausanne). 2024 Jan 26:15:1288326. doi: 10.3389/fendo.2024.1288326. eCollection 2024.

Abstract

This is a narrative review of the progress of research on the correlation between insulin resistance and infertility. Insulin resistance (IR) is not only involved in the development of various metabolic diseases, but also affects female reproductive function, and to some extent is closely related to female infertility. IR may increase the risk of female infertility by activating oxidative stress, interfering with energy metabolism, affecting oocyte development, embryo quality and endometrial tolerance, affecting hormone secretion and embryo implantation, as well as affecting assisted conception outcomes in infertile populations and reducing the success rate of assisted reproductive technology treatment in infertile populations. In addition, IR is closely associated with spontaneous abortion, gestational diabetes and other adverse pregnancies, and if not corrected in time, may increase the risk of obesity and metabolic diseases in the offspring in the long term. This article provides a review of the relationship between IR and infertility to provide new ideas for the treatment of infertility.

Keywords: adverse pregnancy outcomes; assisted reproductive technology; infertility; insulin resistance; offspring health.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Spontaneous*
  • Embryo Implantation
  • Female
  • Humans
  • Infertility, Female* / etiology
  • Infertility, Female* / therapy
  • Insulin Resistance*
  • Pregnancy
  • Reproductive Techniques, Assisted

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the National Natural Science Foundation of China (No. 81501335), the General Program of Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX0086) and the Joint Program of the Chongqing Science and Technology Bureau and the Chongqing Health Commission (No. 2021MSXM141).