Inkjet-Printed Sensors Based on Nanoferrite-Doped Manganese Oxide Nanoparticles for the Sensitive Differential Pulse Voltammetric Determination of Brimonidine

Ameena M Al-Bonayan; Salhah H Alrefaee; Hussain Alessa; Ali Sayqal; Enas H Aljuhani; Roaa T Mogharbel; Fawaz A Saad; Nashwa M El-Metwaly

doi:10.1021/acsomega.3c06553

Inkjet-Printed Sensors Based on Nanoferrite-Doped Manganese Oxide Nanoparticles for the Sensitive Differential Pulse Voltammetric Determination of Brimonidine

ACS Omega. 2024 Jan 22;9(5):5386-5394. doi: 10.1021/acsomega.3c06553. eCollection 2024 Feb 6.

Authors

Ameena M Al-Bonayan¹, Salhah H Alrefaee², Hussain Alessa¹, Ali Sayqal¹, Enas H Aljuhani¹, Roaa T Mogharbel³, Fawaz A Saad¹, Nashwa M El-Metwaly^{1

4}

Affiliations

¹ Department of Chemistry, College of Science, Umm Al-Qura University, Makkah 24231, Saudi Arabia.
² Department of Chemistry, Faculty of Science, Taibah University, Yanbu 30799, Saudi Arabia.
³ Department of Chemistry, Faculty of Science, Northern Border University, Arar 73222, Saudi Arabia.
⁴ Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, El Mansoura 35516, Egypt.

Abstract

The present study described the construction and the electrochemical futures of a novel inject-printed electrochemical sensor based on spinel ferrite-doped manganese oxide nanoparticles (FMnONPs) for the sensitive differential pulse voltammetric quantification of brimonidine (BRIM) in ophthalmic solutions. At the optimized electroanalytical parameters, calibration graphs were linear within the BRIM concentration range of 24-3512 ng mL^-1 and recorded a detection limit value of 8.21 ng mL^-1. Cyclic voltammograms recorded at different scan rates indicated an adsorption-reaction mechanism for the electrooxidation of BRIM at the electrode surface with the involvement of two electrons and one proton based on the oxidation of the five-membered ring nitrogen atom as recommended by the molecular orbital calculations. The enhanced performance of the introduced inkjet-printed sensors integrated with FMnONPs encourages their application for monitoring BRIM residues in ophthalmic solutions and biological fluids in the presence of BRIM degradation products and other interferents for diverse quality control applications.