Current status and perspectives of the quality system in histocompatibility laboratories in Poland

Izabela Uhrynowska-Tyszkiewicz; Katarzyna Bogunia-Kubik; Monika Baj-Krzyworzeka; Barbara Piątosa

doi:10.3389/fgene.2024.1322414

Current status and perspectives of the quality system in histocompatibility laboratories in Poland

Front Genet. 2024 Jan 26:15:1322414. doi: 10.3389/fgene.2024.1322414. eCollection 2024.

Authors

Izabela Uhrynowska-Tyszkiewicz^{1

2}, Katarzyna Bogunia-Kubik³, Monika Baj-Krzyworzeka^{4

5}, Barbara Piątosa^{2

6}

Affiliations

¹ Department of Transplantology and Central Tissue Bank, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
² National Center for Tissue and Cell Banking, Warsaw, Poland.
³ Laboratory of Tissue Immunology, Medical Center, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
⁴ Department of Clinical Immunology, Medical College, Jagiellonian University, Cracow, Poland.
⁵ Tissue Typing Laboratory, Department of Clinical Immunology, University Children's Hospital of Cracow, Cracow, Poland.
⁶ Histocompatibility Laboratory, Children's Memorial Health Institute, Warsaw, Poland.

Abstract

Allogeneic transplantation is a multi-step process involving many clinicians and laboratory personnel working together to achieve a common goal-to maximize the recipients' chance of survival and to improve their quality of life. One of the key elements of the process is to ensure high quality, accuracy, and reliability of histocompatibility testing. This manuscript presents: the development and organizational principles of the national system of supervision and control of histocompatibility laboratories in Poland, problems faced by these laboratories, availabe proficiency testing schemes, as well as suggestions and prospects for the future raised by members of the Polish histocompatibility community.

Keywords: HLA; Poland; histocompatibility; laboratories; quality; transplantation.

Grants and funding

The Authors declare financial support was received for publication of this article. This study was supported by the internal funds of the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Jagiellonian University, Medical College, Cracow, Children’s Memorial Health Institute, Warsaw and Medical University of Warsaw.