Gut microbes in central nervous system development and related disorders

Yumeng Gan; Yao Chen; Huijie Zhong; Zhuo Liu; Jiawei Geng; Huishan Wang; Wenxue Wang

doi:10.3389/fimmu.2023.1288256

Gut microbes in central nervous system development and related disorders

Front Immunol. 2024 Jan 26:14:1288256. doi: 10.3389/fimmu.2023.1288256. eCollection 2023.

Authors

Yumeng Gan^{1

2}, Yao Chen^{1

2}, Huijie Zhong^{1

2

3}, Zhuo Liu^{1

2}, Jiawei Geng^{1

2

4}, Huishan Wang³, Wenxue Wang^{1

2

4

5}

Affiliations

¹ Department of Infectious Disease and Hepatic Disease, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
² School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
³ State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
⁴ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
⁵ School of Basic Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.

Abstract

The association between gut microbiota and central nervous system (CNS) development has garnered significant research attention in recent years. Evidence suggests bidirectional communication between the CNS and gut microbiota through the brain-gut axis. As a long and complex process, CNS development is highly susceptible to both endogenous and exogenous factors. The gut microbiota impacts the CNS by regulating neurogenesis, myelination, glial cell function, synaptic pruning, and blood-brain barrier permeability, with implication in various CNS disorders. This review outlines the relationship between gut microbiota and stages of CNS development (prenatal and postnatal), emphasizing the integral role of gut microbes. Furthermore, the review explores the implications of gut microbiota in neurodevelopmental disorders, such as autism spectrum disorder, Rett syndrome, and Angelman syndrome, offering insights into early detection, prompt intervention, and innovative treatments.

Keywords: Angelman Syndrome; CNS development; Rett Syndrome; autism spectrum disorder; gut microbes.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autism Spectrum Disorder*
Central Nervous System
Central Nervous System Diseases*
Gastrointestinal Microbiome* / physiology
Humans

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by a grant from the National Natural Science Foundation of China (82160514, 82360395), Expert station of Yunnan province (Kunming) (YSZJGZZ-2020051), Eminent Doctors Program of Yunnan Province (YNWR-MY-2019-072), Fundamental Research Projects of Yunnan Province (202101AT070275, 202101AY070001-236, 202101AU070137) and the Foundation of First People’s Hospital of Yunnan Province (KHYJ-6-2020-001, KHBS-2022-028, 2022-KHRCBZ-C06).