Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

Salah Aref; Omnyia Khaled; Nadia El Menshawy; Emad Azmy; Mohamed Aref; Osama Salama; Nada Khaled

doi:10.1186/s43046-024-00209-3

Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

J Egypt Natl Canc Inst. 2024 Feb 12;36(1):5. doi: 10.1186/s43046-024-00209-3.

Authors

Salah Aref¹, Omnyia Khaled², Nadia El Menshawy², Emad Azmy³, Mohamed Aref⁴, Osama Salama², Nada Khaled²

Affiliations

¹ Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt. salaharef@yahoo.com.
² Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt.
³ Hematology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
⁴ Internal Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.

PMID: 38342816
DOI: 10.1186/s43046-024-00209-3

Abstract

Objective: This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients' outcomes.

Methods: SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls.

Results: Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003 respectively) as compared to control, and decline at complete remission (CR) and elevated again at relapse. High SOX2 and OCT3/4 levels were significantly correlated with the presence of adverse risk stratification parameters.

Conclusion: Our findings indicated that both SOX2 and OCT3/4 could serve as biomarkers that could improve risk stratification of acute leukemia patients. Also, both SOX2 and OCT3/4 might be a therapeutic target, especially in resistant acute leukemia.

Keywords: ALL; AML; OCT3/4; Outcome; SOX2.

MeSH terms

Adult
Humans
Leukemia, Myeloid, Acute* / diagnosis
Prognosis
SOXB1 Transcription Factors / genetics

Substances

SOX2 protein, human
SOXB1 Transcription Factors