How Does Anticipated HIV Stigma Affect Medication Adherence? A Longitudinal Path Analysis Model

AIDS Behav. 2024 May;28(5):1684-1693. doi: 10.1007/s10461-024-04293-3. Epub 2024 Feb 10.

Abstract

Prior research has documented that anticipated HIV stigma may play an important predictive role in medication adherence among people living with HIV (PLWH). However, longitudinal data on the mechanisms underlying this linkage are scarce. The current study aimed to explore the longitudinal mediation association among anticipated HIV stigma, medication adherence support, HIV self-management, and medication adherence. A four-wave sample consisting of 1,098 Chinese PLWH (Mage = 38.63, SD = 9.20; 63.9% male) with a six-month interval was used in the current study. Participants were asked to complete self-report questionnaires. A path analysis model was analyzed. Results indicate that anticipated HIV stigma at baseline was positively related to medication adherence at Time 4 (T4). Medication adherence support at Time 2 (T2) and HIV self-management at Time 3 (T3) serially mediated the anticipated HIV stigma at Time 1 (T1) and medication adherence at T4. These findings provide critical insights into the mediating roles of medication adherence support and HIV self-management in the relationship between anticipated HIV stigma and medication adherence over time. Such an understanding has important implications for the development of tailored interventions and public health strategies aimed at improving medication adherence among PLWH in the context of HIV-related stigma.

Keywords: Anticipated HIV stigma; HIV self-management; Medication adherence; Medication adherence support; PLWH.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use
  • China / epidemiology
  • Female
  • HIV Infections* / drug therapy
  • HIV Infections* / psychology
  • Humans
  • Longitudinal Studies
  • Male
  • Medication Adherence* / psychology
  • Medication Adherence* / statistics & numerical data
  • Middle Aged
  • Self Report
  • Self-Management / psychology
  • Social Stigma*
  • Social Support
  • Surveys and Questionnaires

Substances

  • Anti-HIV Agents