Modulation of extrinsic apoptotic pathway by intracellular glycosylation

Kamil Seyrek; Nikita V Ivanisenko; Corinna König; Inna N Lavrik

doi:10.1016/j.tcb.2024.01.003

Modulation of extrinsic apoptotic pathway by intracellular glycosylation

Trends Cell Biol. 2024 Feb 8:S0962-8924(24)00003-5. doi: 10.1016/j.tcb.2024.01.003. Online ahead of print.

Authors

Kamil Seyrek¹, Nikita V Ivanisenko¹, Corinna König¹, Inna N Lavrik²

Affiliations

¹ Translational Inflammation Research, Medical Faculty, Center of Dynamic Systems (CDS), Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
² Translational Inflammation Research, Medical Faculty, Center of Dynamic Systems (CDS), Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany. Electronic address: inna.lavrik@med.ovgu.de.

PMID: 38336591
DOI: 10.1016/j.tcb.2024.01.003

Abstract

The importance of post-translational modifications (PTMs), particularly O-GlcNAcylation, of cytoplasmic proteins in apoptosis has been neglected for quite a while. Modification of cytoplasmic proteins by a single N-acetylglucosamine sugar is a dynamic and reversible PTM exhibiting properties more like phosphorylation than classical O- and N-linked glycosylation. Due to the sparse information existing, we have only limited understanding of how GlcNAcylation affects cell death. Deciphering the role of GlcNAcylation in cell fate may provide further understanding of cell fate decisions. This review focus on the modulation of extrinsic apoptotic pathway via GlcNAcylation carried out by O-GlcNAc transferase (OGT) or by other bacterial effector proteins.

Keywords: NleB; O-GlcNAcylation; OGA; OGT; SseK; apoptosis.

Publication types

Review