Current role of intraoperative cell salvage techniques in the management of renal tumors with level III and IV inferior vena cava thrombus extension

Cristian Surcel; Robert Dotzauer; Cristian Mirvald; Calin Popa; Cosmin Olariu; Catalin Baston; Mihai Harza; Constantin Gangu; Igor Tsaur; Ioanel Sinescu

doi:10.1177/17562872241229248

Current role of intraoperative cell salvage techniques in the management of renal tumors with level III and IV inferior vena cava thrombus extension

Ther Adv Urol. 2024 Feb 7:16:17562872241229248. doi: 10.1177/17562872241229248. eCollection 2024 Jan-Dec.

Authors

Cristian Surcel^{1

2}, Robert Dotzauer³, Cristian Mirvald⁴, Calin Popa⁵, Cosmin Olariu⁶, Catalin Baston^{1

2}, Mihai Harza^{1

2}, Constantin Gangu^{1

2}, Igor Tsaur³, Ioanel Sinescu^{1

2}

Affiliations

¹ Department of Urology, Fundeni Clinical Institute, Bucharest, Romania.
² "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
³ Department of Urology, Johannes Gutenberg University Medical Center, Mainz, Germany.
⁴ Department of Urology, Fundeni Clinical Institute, "Carol Davila" University of Medicine and Pharmacy, 258 Fundeni Street, 2nd District, Bucharest, Romania.
⁵ Cardiac Center, Monza Hospital, Bucharest, Romania.
⁶ Medlife Polisano Hospital, Sibiu, Romania.

Abstract

Background: En bloc removal of the kidney with tumor thrombus excision in a multidisciplinary team remains the standard treatment for renal cell carcinoma (RCC) with tumor thrombus extension. In order to minimize the hemodynamic impact of the surgical blood loss, intraoperative cell salvage (IOCS) techniques can decrease the need for allogeneic blood and prevent blood transfusion related complications.

Objective: In this article, we evaluated the safety of IOCS during radical nephrectomy with inferior vena cava thrombectomy under cardiopulmonary bypass with or without deep hypothermic circulatory arrest.

Design and method: In this retrospective comparative multicenter analysis, clinical characteristics of 27 consecutive patients who underwent surgery with or without IOCS between 2012 and 2022 in three referral care units were collected into a database. The need for an allogenic blood transfusion (ABT) was also recorded, defined as any transfusion that occurred either intraoperatively or during the hospital stay.

Results: The need for ABT in the cell saver arm was significantly smaller due to the reinfusion of rescued blood (p < 0.015). In multivariate analysis, no cell saver usage was an independent predictor for complications ⩾3 Clavien 3a [odds ratio (OR) 18.71, 95% CI 1.056-331.703, p = 0.046]. No usage of IOCS was an independent predictor for a lower risk of death (OR 0.277, 95% CI 0.062-0.825, p = 0.024). During follow-up, patients who received salvaged blood did not experience an increased risk for developing local recurrence or distant metastases.

Conclusion: Transfusion of autologous blood is safe and can be using during nephrectomy and thrombectomy for advanced RCC.

Keywords: advanced renal cell carcinoma; blood management; cavoatrial extension; intraoperative cell salvage techniques; oncological outcomes.

Plain language summary

Role of intraoperative cell salvage techniques in the management of renal tumors with advanced caval extension En bloc removal of the kidney with tumor thrombus excision in a multidisciplinary team remains the standard treatment for RCC with tumor thrombus extension. Intraoperative cell salvage techniques (IOCS) can decrease the need for allogeneic blood and prevent blood transfusion related complications. In this article we demonstrated that transfusion of autologous blood is safe and can be using during nephrectomy and thrombectomy for advanced renal cell carcinoma.