SOX on tumors, a comfort or a constraint?

Junqing Jiang; Yufei Wang; Mengyu Sun; Xiangyuan Luo; Zerui Zhang; Yijun Wang; Siwen Li; Dian Hu; Jiaqian Zhang; Zhangfan Wu; Xiaoping Chen; Bixiang Zhang; Xiao Xu; Shuai Wang; Shengjun Xu; Wenjie Huang; Limin Xia

doi:10.1038/s41420-024-01834-6

SOX on tumors, a comfort or a constraint?

Cell Death Discov. 2024 Feb 9;10(1):67. doi: 10.1038/s41420-024-01834-6.

Authors

Junqing Jiang^#¹, Yufei Wang^#¹, Mengyu Sun^#¹, Xiangyuan Luo¹, Zerui Zhang¹, Yijun Wang¹, Siwen Li¹, Dian Hu¹, Jiaqian Zhang¹, Zhangfan Wu¹, Xiaoping Chen², Bixiang Zhang², Xiao Xu³, Shuai Wang^{3

4}, Shengjun Xu³, Wenjie Huang⁵, Limin Xia⁶

Affiliations

¹ Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.
² Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei, 430030, China.
³ Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
⁴ Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Westlake university school of medicine, Hangzhou, 310006, China.
⁵ Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei, 430030, China. huangwenjie@tjh.tjmu.edu.cn.
⁶ Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China. xialimin@tjh.tjmu.edu.cn.

^# Contributed equally.

Abstract

The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation of SOX family members is closely associated with tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research to investigate the mechanisms and functions of the SOX family, confusion remains regarding aspects such as the role of the SOX family in tumor immune microenvironment (TIME) and contradictory impacts the SOX family exerts on tumors. This review summarizes the physiological function of the SOX family and their multiple roles in tumors, with a focus on the relationship between the SOX family and TIME, aiming to propose their potential role in cancer and promising methods for treatment.

Publication types

Review

Abstract

Publication types

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