Design of neural organoids engineered by mechanical forces

Dang Ngoc Anh Suong; Keiko Imamura; Yoshikazu Kato; Haruhisa Inoue

doi:10.1016/j.ibneur.2024.01.004

Design of neural organoids engineered by mechanical forces

IBRO Neurosci Rep. 2024 Jan 24:16:190-195. doi: 10.1016/j.ibneur.2024.01.004. eCollection 2024 Jun.

Authors

Dang Ngoc Anh Suong^{1

2}, Keiko Imamura^{1

2

3}, Yoshikazu Kato⁴, Haruhisa Inoue^{1

2

3}

Affiliations

¹ iPSC‑Based Drug Discovery and Development Team, RIKEN BioResource Research Center (BRC), Kyoto, Japan.
² Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
³ Medical‑Risk Avoidance Based On iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto, Japan.
⁴ Mixing Technology Laboratory, SATAKE MultiMix Corporation, Saitama, Japan.

Abstract

Neural organoids consist of three-dimensional tissue derived from pluripotent stem cells that could recapitulate key features of the human brain. During the past decade, organoid technology has evolved in the field of human brain science by increasing the quality and applicability of its products. Among them, a novel approach involving the design of neural organoids engineered by mechanical forces has emerged. This review describes previous approaches for the generation of neural organoids, the engineering of neural organoids by mechanical forces, and future challenges for the application of mechanical forces in the design of neural organoids.

Keywords: Bioreactor; Engineering; Fluid dynamics; Mechanical force; Neural organoid; iPSCs.

Publication types

Review