Chimeric RNAs and their implication in prostate cancer

Hui Li; Qiong Wang

doi:10.1016/j.cpt.2023.04.003

Chimeric RNAs and their implication in prostate cancer

Cancer Pathog Ther. 2023 May 1;1(3):216-219. doi: 10.1016/j.cpt.2023.04.003. eCollection 2023 Jul.

Authors

Hui Li¹, Qiong Wang²

Affiliations

¹ Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
² Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.

Abstract

•Chimeric ribonucleic acids (RNAs) form through gene fusion, trans-splicing, or cis-splicing between adjacent genes (cis-SAGe) mechanisms•Chimeric RNAs influence prostate cancer (PCa) progression by acting as long noncoding RNAs (lncRNAs) or circular RNAs (circRNAs), coding fusion proteins, and misregulating parental genes•Misregulated chimeric RNAs represent a novel repertoire for biomarkers and targets for PCa therapy.

Keywords: Chimeric RNAs; Cis-SAGe; Prostate cancer; Trans-splicing.

Publication types

Review