Congenital Diaphragmatic Hernia: Pulmonary Hypertension and Pulmonary Vascular Disease

Shiran S Moore; Roberta L Keller; Gabriel Altit

doi:10.1016/j.clp.2023.10.001

Congenital Diaphragmatic Hernia: Pulmonary Hypertension and Pulmonary Vascular Disease

Clin Perinatol. 2024 Mar;51(1):151-170. doi: 10.1016/j.clp.2023.10.001. Epub 2023 Nov 10.

Authors

Shiran S Moore¹, Roberta L Keller², Gabriel Altit³

Affiliations

¹ Neonatology, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Weizamann 6, Tel-Aviv, Jaffa 6423906, Israel. Electronic address: shiransm@tlvmc.gov.il.
² Neonatology, UCSF Benioff Children's Hospital, 550 16th Street, #5517, San Francisco, CA 94158, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
³ Neonatology, McGill University Health Centre, Montreal Children's Hospital, 1001 Décarie boulevard, Montreal, H4A Quebec; Department of Pediatrics, McGill University, Montreal, Quebec, Canada.

PMID: 38325939
DOI: 10.1016/j.clp.2023.10.001

Abstract

This review provides a comprehensive summary of the current understanding of pulmonary hypertension (PH) in congenital diaphragmatic hernia, outlining the underlying pathophysiologic mechanisms, methods for assessing PH severity, optimal management strategies, and prognostic implications.

Keywords: Cardiopulmonary interactions; Congenital diaphragmatic hernia; Inotropes; Pulmonary hypertension; Vasodilators; Ventilation.

Publication types

Review

MeSH terms

Hernias, Diaphragmatic, Congenital* / complications
Hernias, Diaphragmatic, Congenital* / surgery
Humans
Hypertension, Pulmonary* / diagnosis
Hypertension, Pulmonary* / therapy
Lung / abnormalities
Lung / diagnostic imaging
Prognosis
Severity of Illness Index