Sagittal Abdominal Diameter as the Best Predictor of Metabolic Syndrome in HIV-Infected Men on Antiretroviral Therapy

Zorka Drvendžija; Biljana Srdić Galić; Miloš Vujanović; Daniela Marić; Nina Brkić Jovanović; Snežana Brkić; Vesna Turkulov; Dalibor Ilić

doi:10.2174/011570162X270929240125055222

Sagittal Abdominal Diameter as the Best Predictor of Metabolic Syndrome in HIV-Infected Men on Antiretroviral Therapy

Curr HIV Res. 2024 Feb 7. doi: 10.2174/011570162X270929240125055222. Online ahead of print.

Authors

Zorka Drvendžija¹, Biljana Srdić Galić¹, Miloš Vujanović², Daniela Marić^{3

4}, Nina Brkić Jovanović⁵, Snežana Brkić^{3

4}, Vesna Turkulov^{3

4}, Dalibor Ilić⁶

Affiliations

¹ Department of Anatomy, Medical Faculty, University of Novi Sad, Novi Sad, Serbia.
² Institut für Diagnostische und Interventionelle Radiologie/Neuroradiologie, Klinikum Passau, Passau, Germany.
³ Department of Infectious Diseases, Medical Faculty, University of Novi Sad, Novi Sad, Serbia.
⁴ Clinic for Infectious Diseases, University Clinical Center of Vojvodina, Novi Sad, Serbia.
⁵ Department of Psychology, Medical Faculty, University of Novi Sad, Novi Sad, Serbia.
⁶ Center for Radiology, University Clinical Center of Vojvodina, Novi Sad, Serbia.

PMID: 38323612
DOI: 10.2174/011570162X270929240125055222

Abstract

Background: The interaction of human immunodeficiency virus (HIV), host and antiretroviral therapy causes a range of metabolic disorders that can be characterized as a metabolic syndrome (MetS) that increases the cardiovascular risk. MetS involves central obesity, which can be detected using different anthropometric parameters.

Objective: To assess the abilities of different anthropometric parameters in the prediction of MetS in HIV-infected men on ART.

Method: The study involved 92 male participants (mean age 44.46±10.38 years), divided into two groups: with and without MetS. All subjects underwent biochemical evaluation (triglycerides, HDL-cholesterol, fasting glucose), blood pressure measurement and anthropometric assessment: body mass, body height, body mass index (BMI), body fat mass, body circumferences (chest, upper arm, forearm, waist, hip, proximal and middle thigh and calf), sagittal abdominal diameter (SAD), skinfold thicknesses (subscapular, anterior and posterior upper arm, anterior and lateral forearm, abdominal, supraspinal, thigh and calf), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), waist-to-thigh ratio (WTR), sagittal abdominal diameter-to-body height ratio (SADH), body adiposity index (BAI) and conicity index. MetS was specified according to IDF criteria.

Results: Subjects with MetS had statistically significant higher values of all anthropometric parameters except middle thigh circumference, calf skinfold and body height. According to ROC analysis and Binary Logistic Regression, SAD has been shown as the best predictor of MetS with a predictive value of 21.40 cm (AUC:0.91), followed by WHR with a predictive value of 0.93.

Conclusion: Sagittal abdominal diameter is the strongest anthropometric indicator of MetS in HIV-infected patients on ART.

Keywords: Anthropometry; Antiretroviral Therapy; Cardiovascular Risk; HIV; Men; Metabolic Syndrome.