Microbial Profile, Antimicrobial Susceptibility, and Prevalence of MDR/XDR Pathogens Causing Medical Device Associated Infections: A Single Center Study

Vaibhav R Suryawanshi; Atmaram Pawar; Bharat Purandare; Niveda Vijayvargiya; Sandesh Sancheti; Susan Philip; Prasad Nagare

doi:10.5005/jp-journals-10071-24623

Microbial Profile, Antimicrobial Susceptibility, and Prevalence of MDR/XDR Pathogens Causing Medical Device Associated Infections: A Single Center Study

Indian J Crit Care Med. 2024 Feb;28(2):152-164. doi: 10.5005/jp-journals-10071-24623.

Authors

Vaibhav R Suryawanshi¹, Atmaram Pawar², Bharat Purandare³, Niveda Vijayvargiya¹, Sandesh Sancheti¹, Susan Philip¹, Prasad Nagare¹

Affiliations

¹ Department of Pharmacy Practice, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, BVDU Katraj Campus, Pune, Maharashtra, India.
² Department of Pharmaceutics, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Pune, Maharashtra, India.
³ Department of Infectious Diseases, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, India.

Abstract

Background: There is a scarcity of studies evaluating the microbial profile, antimicrobial susceptibility, and prevalence of MDR/XDR pathogens causing medical device-associated infections (MDAIs). The present study was sought in this regard.

Materials and methods: An ambispective-observational, site-specific, surveillance-based study was performed for a period of 2 years in the intensive care unit (ICU) and high dependency unit (HDU) (medicine/surgery) of a Tertiary-care University Hospital. Three commonly encountered MDAIs including central-line-associated bloodstream infections (CLABSI), catheter-associated urinary tract infections (CAUTI), and ventilator-associated pneumonia (VAP), were targeted.

Results and conclusion: Of the total 90 patients, 46 (51.1%) were admitted to the ICU (medicine/surgery), and the remaining 44 (48.8%) were admitted to the HDU (medicine/surgery). The median (P₂₅-P₇₅) age of the total patients was 55 (43.1-62.3) years. Male 61 (67.8%) preponderance was observed. Sixty-two of 90 (68.9%) were immunocompromised. A total of 104 pathogens causing MDAIs were isolated. Staphylococcus epidermidis (CoNS), and Staphylococcus capitis were commonly isolated multi-drug resistant (MDR) gram-positive pathogens causing MDAIs. Similarly, carba-resistant Klebsiella pneumoniae, Stenotrophomonas maltophilia, and carba-resistant Acinetobacter baumanni were commonly isolated MDR gram-negative pathogens causing MDAIs. Five of 9 (55.5%) K. pneumoniae and three of 9 (33.3%) S. maltophilia isolates were found to be extensively drug resistant. Among Candida, C. parapsilosis was the most prevalent fungal pathogen causing CLABSI and CAUTI in patients admitted to ICU/HDU.

How to cite this article: Suryawanshi VR, Pawar A, Purandare B, Vijayvargiya N, Sancheti S, Philip S, et al. Microbial Profile, Antimicrobial Susceptibility, and Prevalence of MDR/XDR Pathogens Causing Medical Device Associated Infections: A Single Center Study. Indian J Crit Care Med 2024;28(2):152-164.

Keywords: Antimicrobial susceptibility; MDR/XDR; Medical device-associated infections; Microbial profile.