Scrub Typhus: An Acute Precipitant for Acute on Chronic Liver Failure

J Clin Exp Hepatol. 2024 May-Jun;14(3):101344. doi: 10.1016/j.jceh.2024.101344. Epub 2024 Jan 9.

Abstract

Acute-on-chronic liver failure (ACLF) is a clinical syndrome with high mortality. Many acute precipitating factors have been implicated in triggering the acute event of ACLF, with bacterial infections being a common precipitant. However, many other precipitants can cause ACLF; therefore, identification of these factors early in the golden window and their treatment can result in improved prognosis. Scrub typhus usually presents as uncomplicated acute febrile illness but rarely as complicated. Few case reports of scrub-typhus-induced acute liver failure have been reported but none with scrub-typhus-precipitating ACLF so far. Therefore, we are reporting a case of scrub-typhus-precipitating ACLF, where timely intervention with antibiotics results in improved outcome.

Keywords: acute-on-chronic liver failure; liver Infections; liver cirrhosis; rickettsial infection; scrub typhus.

Publication types

  • Case Reports