High-Dose Glucocorticoids for the Treatment of Sudden Hearing Loss

NEJM Evid. 2024 Jan;3(1):EVIDoa2300172. doi: 10.1056/EVIDoa2300172. Epub 2023 Dec 26.

Abstract

High-Dose Glucocorticoids for Sudden Hearing LossThis trial compared courses of high-dose intravenous prednisolone or high-dose oral dexamethasone versus standard-dose oral prednisone in adults with idiopathic sudden sensorineural hearing loss. At 30 days, systemic high-dose glucocorticoid therapy was not superior to a lower-dose regimen with respect to change in hearing threshold, and it was associated with a higher risk of side effects.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Dexamethasone
  • Glucocorticoids*
  • Hearing Loss, Sudden* / chemically induced
  • Humans
  • Prednisone
  • Treatment Outcome

Substances

  • Dexamethasone
  • Glucocorticoids
  • Prednisone