Apixaban versus Aspirin for Embolic Stroke of Undetermined Source

NEJM Evid. 2024 Jan;3(1):EVIDoa2300235. doi: 10.1056/EVIDoa2300235. Epub 2023 Dec 22.

Abstract

Apixaban versus Aspirin for Embolic StrokeIn a trial of 352 patients with embolic stroke of undetermined source, 5 mg of apixaban administered twice daily was compared with 100 mg of aspirin administered once daily for the prevention of recurrent ischemic strokes. At 12 months, 13.6% of patients given apixaban had new ischemic lesions on magnetic resonance imaging compared with 16.0% of patients given aspirin, and the rates of clinically relevant bleeding were also comparable.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Aspirin
  • Double-Blind Method
  • Embolic Stroke*
  • Humans
  • Pyrazoles*
  • Pyridones*
  • Stroke* / prevention & control

Substances

  • apixaban
  • Aspirin
  • Pyrazoles
  • Pyridones