Ropeginterferon versus Standard Therapy for Low-Risk Patients with Polycythemia Vera

NEJM Evid. 2023 Jun;2(6):EVIDoa2200335. doi: 10.1056/EVIDoa2200335. Epub 2023 May 15.

Abstract

Ropeginterferon for Patients with Polycythemia VeraPatients with low-risk polycythemia vera were randomly assigned to receive ropeginterferon alfa-2b and phlebotomy or phlebotomy alone. The trial met its end point of maintenance of a hematocrit target (≤45%) without thrombotic events, progression of leukocytosis, thrombocytosis, and worsening of splenomegaly in the ropeginterferon alfa-2b group.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Humans
  • Leukocytosis
  • Polycythemia Vera*
  • Polycythemia*
  • Thrombocytosis*
  • Thrombosis*