A Bayesian Interpretation of a Pediatric Cardiac Arrest Trial (THAPCA-OH)

Michael O Harhay; Bryan S Blette; Anders Granholm; Frank W Moler; Fernando G Zampieri; Ewan C Goligher; Monique M Gardner; Alexis A Topjian; Nadir Yehya

doi:10.1056/EVIDoa2200196

A Bayesian Interpretation of a Pediatric Cardiac Arrest Trial (THAPCA-OH)

NEJM Evid. 2023 Jan;2(1):EVIDoa2200196. doi: 10.1056/EVIDoa2200196. Epub 2022 Dec 14.

Authors

Michael O Harhay^{1

2}, Bryan S Blette^{1

2}, Anders Granholm³, Frank W Moler⁴, Fernando G Zampieri^{5

6}, Ewan C Goligher^{7

8

9}, Monique M Gardner¹⁰, Alexis A Topjian¹⁰, Nadir Yehya¹⁰

Affiliations

¹ Clinical Trials Methods and Outcomes Lab, Palliative and Advanced Illness Research Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
² Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
³ Department of Intensive Care 4131, Copenhagen University Hospital-Rigshospitalet, Copenhagen.
⁴ Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI.
⁵ Academic Research Organization, Hospital Albert Einstein, São Paulo.
⁶ Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, AB, Canada.
⁷ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto.
⁸ Department of Medicine, Division of Respirology, University Health Network, Toronto.
⁹ Toronto General Hospital Research Institute, Toronto.
¹⁰ Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia.

PMID: 38320098
DOI: 10.1056/EVIDoa2200196

Abstract

Bayesian Reanalysis of Pediatric Cardiac Arrest TrialOnly 7,000 children experience out-of-hospital cardiac arrest annually in the United States, and thus it is difficult to conduct large trials. This study presents a way to leverage all existing data by conducting a Bayesian reanalysis of the THAPCA-OH (Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital) trial.

MeSH terms

Bayes Theorem
Child
Humans
Hypothermia, Induced*
Out-of-Hospital Cardiac Arrest* / therapy
United States