Anticoagulation Strategies in Non-Critically Ill Patients with Covid-19

Zoe K McQuilten; Balasubramanian Venkatesh; Vivekanand Jha; Jason Roberts; Susan C Morpeth; James A Totterdell; Grace M McPhee; John Abraham; Niraj Bam; Methma Bandara; Ashpak K Bangi; Lauren A Barina; Bhupendra K Basnet; Hasan Bhally; Khema R Bhusal; Umesh Bogati; Asha C Bowen; Andrew J Burke; Devasahayam J Christopher; Sanjeev D Chunilal; Belinda Cochrane; Jennifer L Curnow; Santa Kumar Das; Ashesh Dhungana; Gian Luca Di Tanna; Ravindra Dotel; Hyjel DSouza; Jack Dummer; Sourabh Dutta; Hong Foo; Timothy L Gilbey; Michelle L Giles; Kasiram Goli; Adrienne Gordon; Pradip Gyanwali; Dipak Haksar; Bernard J Hudson; Manoj K Jani; Purnima R Jevaji; Sachin Jhawar; Aikaj Jindal; M Joseph John; Mary John; Flavita B John; Oommen John; Mark Jones; Rajesh D Joshi; Prashanthi Kamath; Gagandeep Kang; Achyut R Karki; Abhishek M Karmalkar; Baldeep Kaur; Kalyan Chakravarthy Koganti; Jency M Koshy; Mathew S Krishnamurthy; Jillian S Lau; Sharon R Lewin; Lyn-Li Lim; Ian C Marschner; Julie A Marsh; Michael J Maze; James M McGree; James H McMahon; Robert L Medcalf; Eileen G Merriman; Amol P Misal; Jocelyn M Mora; Vijaybabu K Mudaliar; Vi Nguyen; Matthew V O'Sullivan; Suman Pant; Pankaj Pant; David L Paterson; David J Price; Megan A Rees; James O Robinson; Benjamin A Rogers; Sandhya Samuel; Joe Sasadeusz; Deepak Sharma; Prabhat K Sharma; Roshan Shrestha; Sailesh K Shrestha; Prajowl Shrestha; Urvi Shukla; Omar Shum; Christine Sommerville; Tim Spelman; Richard P Sullivan; Umashankar Thatavarthi; Huyen A Tran; Nanette Trask; Clare L Whitehead; Robert K Mahar; Naomi E Hammond; James D McFadyen; Thomas L Snelling; Joshua S Davis; Justin T Denholm; Steven Y C Tong

doi:10.1056/EVIDoa2200293

Anticoagulation Strategies in Non-Critically Ill Patients with Covid-19

NEJM Evid. 2023 Feb;2(2):EVIDoa2200293. doi: 10.1056/EVIDoa2200293. Epub 2022 Dec 10.

Authors

Zoe K McQuilten^{1

2}, Balasubramanian Venkatesh^{3

4

5

6

7}, Vivekanand Jha^{5

8}, Jason Roberts^{3

9}, Susan C Morpeth¹⁰, James A Totterdell¹¹, Grace M McPhee¹², John Abraham¹³, Niraj Bam¹⁴, Methma Bandara¹², Ashpak K Bangi¹⁵, Lauren A Barina¹², Bhupendra K Basnet¹⁶, Hasan Bhally¹⁷, Khema R Bhusal¹⁸, Umesh Bogati¹⁶, Asha C Bowen^{19

20}, Andrew J Burke^{3

21}, Devasahayam J Christopher²², Sanjeev D Chunilal^{1

23}, Belinda Cochrane^{24

25}, Jennifer L Curnow^{11

26}, Santa Kumar Das¹⁸, Ashesh Dhungana¹⁶, Gian Luca Di Tanna⁴, Ravindra Dotel²⁷, Hyjel DSouza⁵, Jack Dummer^{28

29}, Sourabh Dutta³⁰, Hong Foo³¹, Timothy L Gilbey³², Michelle L Giles^{1

12}, Kasiram Goli³³, Adrienne Gordon^{11

34}, Pradip Gyanwali^{14

18}, Dipak Haksar³⁵, Bernard J Hudson³⁶, Manoj K Jani³⁷, Purnima R Jevaji⁵, Sachin Jhawar³⁷, Aikaj Jindal³⁸, M Joseph John¹³, Mary John¹³, Flavita B John²², Oommen John^{5

39}, Mark Jones¹¹, Rajesh D Joshi⁵, Prashanthi Kamath⁵, Gagandeep Kang²², Achyut R Karki¹⁶, Abhishek M Karmalkar⁴⁰, Baldeep Kaur⁴, Kalyan Chakravarthy Koganti⁴¹, Jency M Koshy⁴², Mathew S Krishnamurthy⁴², Jillian S Lau^{43

44}, Sharon R Lewin^{2

12}, Lyn-Li Lim¹, Ian C Marschner¹¹, Julie A Marsh¹⁹, Michael J Maze²⁸, James M McGree⁴⁵, James H McMahon⁴⁴, Robert L Medcalf¹, Eileen G Merriman¹⁷, Amol P Misal⁴⁶, Jocelyn M Mora¹², Vijaybabu K Mudaliar⁵, Vi Nguyen¹², Matthew V O'Sullivan^{11

26

31}, Suman Pant¹⁸, Pankaj Pant¹⁴, David L Paterson⁴⁷, David J Price^{12

48}, Megan A Rees⁴⁹, James O Robinson^{50

51}, Benjamin A Rogers^{1

2}, Sandhya Samuel¹³, Joe Sasadeusz^{12

52}, Deepak Sharma⁵³, Prabhat K Sharma⁵³, Roshan Shrestha¹⁸, Sailesh K Shrestha¹⁶, Prajowl Shrestha¹⁶, Urvi Shukla⁵⁴, Omar Shum^{55

56}, Christine Sommerville¹², Tim Spelman^{57

58}, Richard P Sullivan^{59

60}, Umashankar Thatavarthi⁴¹, Huyen A Tran^{1

44}, Nanette Trask⁶¹, Clare L Whitehead⁶², Robert K Mahar^{48

63}, Naomi E Hammond^{4

36}, James D McFadyen^{44

64}, Thomas L Snelling^{11

19}, Joshua S Davis^{60

65}, Justin T Denholm^{12

52}, Steven Y C Tong^{12

52}

Affiliations

¹ Monash University, Melbourne, Australia.
² Monash Health, Melbourne, Australia.
³ University of Queensland, Brisbane, Australia.
⁴ The George Institute for Global Health, Sydney, Australia.
⁵ The George Institute for Global Health, Delhi, Delhi, India.
⁶ The Wesley Hospital, Brisbane, Queensland, Australia.
⁷ University of New South Wales, Sydney, New South Wales, Australia.
⁸ Imperial College, London, England, United Kingdom.
⁹ Metro North Health, Brisbane, Queensland, Australia.
¹⁰ Middlemore Hospital, Auckland, North Island, New Zealand.
¹¹ Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
¹² Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
¹³ Christian Medical College, Ludhiana, Punjab, India.
¹⁴ Institute of Medicine, Maharajgunj Medical Campus, Kathmandu, Bagmati, Nepal.
¹⁵ Jivanrekha Multispeciality Hospital, Pune, Maharashtra, India.
¹⁶ National Academy of Medical Sciences, Bir Hospital, Kathmandu, Bagmati, Nepal.
¹⁷ North Shore Hospital, Auckland, North Island, New Zealand.
¹⁸ Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Bagmati, Nepal.
¹⁹ Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.
²⁰ Perth Children's Hospital, Perth, Western Australia, Australia.
²¹ The Prince Charles Hospital, Brisbane, Queensland, Australia.
²² Christian Medical College, Vellore, Tamil Nadu, India.
²³ Monash Medical Centre, Melbourne, Victoria, Australia.
²⁴ Campbelltown Hospital, Campbelltown, New South Wales, Australia.
²⁵ Western Sydney University, Sydney, New South Wales, Australia.
²⁶ Westmead Hospital, Sydney, New South Wales, Australia.
²⁷ Blacktown Hospital, Sydney, New South Wales, Australia.
²⁸ University of Otago, Dunedin, Otago, New Zealand.
²⁹ Dunedin Hospital, Dunedin, Otago, New Zealand.
³⁰ Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.
³¹ NSW Health Pathology, Sydney, New South Wales, Australia.
³² Wagga Wagga Base Hospital, Wagga Wagga, New South Wales, Australia.
³³ Aditya Multi-speciality Hospital, Guntur, Andhra Pradesh, India.
³⁴ Royal Prince Alfred Hospital, Newborn Care, Melbourne, Victoria, Australia.
³⁵ ITC Hotels, Gurugram, Haryana, India.
³⁶ Royal North Shore Hospital, Sydney, New South Wales, Australia.
³⁷ Apex Hospitals, Jaipur, Rajasthan, India.
³⁸ Satguru Partap Singh Hospitals, Ludhiana, Punjab, India.
³⁹ Manipal Academy of Higher Education, Udupi, Karnataka, India.
⁴⁰ Sterling Multispeciality Hospital, Pune, Maharashtra, India.
⁴¹ Samishta Hospital & Research Institute, Guntur, Andhra Pradesh, India.
⁴² Believers Church Medical College Hospital, Thiruvalla, Kerala, India.
⁴³ Eastern Health, Melbourne, Victoria, Australia.
⁴⁴ The Alfred Hospital, Melbourne, Victoria, Australia.
⁴⁵ Queensland University of Technology, Brisbane, Queensland, Australia.
⁴⁶ Core Hospital, Chakan, Maharashtra, India.
⁴⁷ National Institute of Singapore, Singapore, Singapore, Singapore.
⁴⁸ Melbourne School of Population & Global Health, University of Melbourne, Melbourne, Victoria, Australia.
⁴⁹ Respiratory and Sleep Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
⁵⁰ College of Science, Health, Engineering and Education, Discipline of Health, Murdoch University, Perth, Western Australia, Australia.
⁵¹ PathWest Laboratory Medicine, Perth, Western Australia, Australia.
⁵² Victorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
⁵³ Maharaja Agrasen Superspeciality Hospital, Delhi, Delhi, India.
⁵⁴ Symbiosis University Hospital & Research Centre, Pune, Maharashtra, India.
⁵⁵ The Wollongong Hospital, Wollongong, New South Wales, Australia.
⁵⁶ University of Wollongong, Wollongong, New South Wales, Australia.
⁵⁷ Karolinska Institute, Solna, Stockholm, Sweden.
⁵⁸ Burnet Institute, Melbourne, Victoria, Australia.
⁵⁹ St. George Hospital, School of Clinical Medicine, UNSW Medicine & Health, Sydney, New South Wales, Australia.
⁶⁰ Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
⁶¹ Chartered Accountants Australia and New Zealand, Perth, Western Australia, Australia.
⁶² The Royal Women's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
⁶³ Murdoch Children's Research Institute, Perth, Western Australia, Australia.
⁶⁴ Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
⁶⁵ University of Newcastle, Newcastle, New South Wales, Australia.

PMID: 38320033
DOI: 10.1056/EVIDoa2200293

Abstract

Anticoagulation in Non-Critically Ill Covid-19 PatientsMcQuilten et al. conducted a randomized clinical trial comparing low-dose, intermediate-dose, low-dose plus aspirin, and therapeutic-dose anticoagulation in patients with Covid-19 of diverse ethnicities in high-, low-, and middle-income countries.

Publication types

Randomized Controlled Trial

MeSH terms

Anticoagulants / pharmacology
Aspirin / pharmacology
Blood Coagulation
COVID-19*
Humans

Substances

Anticoagulants
Aspirin