Meta-Analysis of Candidate Surrogate End Points in Advanced Prostate Cancer

Laila A Gharzai; Ralph Jiang; Elizabeth M Jaworski; Krystal Morales Rivera; Robert T Dess; William C Jackson; Holly E Hartman; Rohit Mehra; Amar U Kishan; Abhishek A Solanki; Edward M Schaeffer; Felix Y Feng; Nicholas G Zaorsky; Alejandro Berlin; Lee Ponsky; Jonathan Shoag; Yilun Sun; Matthew J Schipper; Jorge Garcia; Daniel E Spratt

doi:10.1056/EVIDoa2200195

Meta-Analysis of Candidate Surrogate End Points in Advanced Prostate Cancer

NEJM Evid. 2023 Apr;2(4):EVIDoa2200195. doi: 10.1056/EVIDoa2200195. Epub 2023 Mar 27.

Authors

Laila A Gharzai¹, Ralph Jiang², Elizabeth M Jaworski³, Krystal Morales Rivera³, Robert T Dess³, William C Jackson³, Holly E Hartman⁴, Rohit Mehra⁵, Amar U Kishan⁶, Abhishek A Solanki⁷, Edward M Schaeffer⁸, Felix Y Feng⁹, Nicholas G Zaorsky¹⁰, Alejandro Berlin¹¹, Lee Ponsky¹², Jonathan Shoag¹², Yilun Sun⁴, Matthew J Schipper^{2

3}, Jorge Garcia¹³, Daniel E Spratt¹⁰

Affiliations

¹ Department of Radiation Oncology, Northwestern University, Chicago.
² Department of Biostatistics, University of Michigan, Ann Arbor.
³ Department of Radiation Oncology, University of Michigan, Ann Arbor.
⁴ Department of Population and Quantitative Health Sciences, Case Western Reserve, Cleveland, OH.
⁵ Department of Pathology, University of Michigan, Ann Arbor.
⁶ Department of Radiation Oncology, University of California, Los Angeles, Los Angeles.
⁷ Department of Radiation Oncology, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL.
⁸ Department of Urology, Northwestern University, Chicago.
⁹ Department of Radiation Oncology, University of California, San Francisco, San Francisco.
¹⁰ Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve, Cleveland, OH.
¹¹ Department of Radiation Oncology, University of Toronto; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON.
¹² Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve, Cleveland, OH.
¹³ Department of Medicine, University Hospitals Seidman Cancer Center, Case Western Reserve, Cleveland, OH.

PMID: 38320030
DOI: 10.1056/EVIDoa2200195

Abstract

Meta-Analysis of Surrogate End Points in Prostate CancerGharzai et al. report on the results of a meta-analysis, which concludes that unlike the case in localized prostate cancer, surrogate end points in advanced prostate cancer may not track overall survival.

Publication types

Meta-Analysis

MeSH terms

Biomarkers
Humans
Male
Prostate
Prostatic Neoplasms*

Substances

Biomarkers