Sacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction

Martina D Liechti; Stéphanie van der Lely; Stephanie C Knüpfer; Dominik Abt; Bernhard Kiss; Lorenz Leitner; Livio Mordasini; Jure Tornic; Jens Wöllner; Ulrich Mehnert; Lucas M Bachmann; Fiona C Burkhard; Daniel S Engeler; Jürgen Pannek; Thomas M Kessler

doi:10.1056/EVIDoa2200071

Sacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction

NEJM Evid. 2022 Nov;1(11):EVIDoa2200071. doi: 10.1056/EVIDoa2200071. Epub 2022 Jul 7.

Authors

Martina D Liechti¹, Stéphanie van der Lely¹, Stephanie C Knüpfer^{1

2}, Dominik Abt^{3

4}, Bernhard Kiss⁵, Lorenz Leitner¹, Livio Mordasini^{3

6}, Jure Tornic^{1

7}, Jens Wöllner⁸, Ulrich Mehnert¹, Lucas M Bachmann⁹, Fiona C Burkhard⁵, Daniel S Engeler³, Jürgen Pannek^{5

8}, Thomas M Kessler¹

Affiliations

¹ Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
² Department of Urology, University Hospital of Bonn, Bonn, Germany.
³ Department of Urology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
⁴ Department of Urology, Spitalzentrum Biel/Centre Hospitalier Bienne, Biel/Bienne, Switzerland.
⁵ Department of Urology, Bern University Hospital, University of Bern, Bern, Switzerland.
⁶ URO-Sursee, Uroviva, Sursee, Switzerland.
⁷ Clinic for Urology, Kantonsspital Winterthur, Winterthur, Switzerland.
⁸ Neuro-Urology, Swiss Paraplegic Center, Nottwil, Switzerland.
⁹ Medignition Inc., Research Consultants, Zürich, Switzerland.

PMID: 38319849
DOI: 10.1056/EVIDoa2200071

Abstract

SNM for Urinary Tract DysfunctionThis study evaluated SNM for neurogenic lower urinary tract dysfunction. A neurostimulator was implanted for permanent stimulation and optimized using subsensory stimulation. It remained on or was switched off, with patients masked to the condition. After 2 months, the SNM ON group had significantly different success compared with the SNM OFF group (76% vs. 42%).

MeSH terms

Electric Stimulation Therapy*
Electrodes, Implanted
Humans
Lower Urinary Tract Symptoms* / therapy
Sacrum
Urinary Tract*