Abiraterone and Olaparib for Metastatic Castration-Resistant Prostate Cancer

NEJM Evid. 2022 Sep;1(9):EVIDoa2200043. doi: 10.1056/EVIDoa2200043. Epub 2022 Jun 3.

Abstract

Abiraterone and Olaparib for Metastatic Prostate CancerPatients with metastatic castration-resistant prostate cancer, regardless of homologous recombination repair gene mutation status, received either abiraterone and olaparib or abiraterone and placebo in the first-line setting. Imaging-based progression-free survival was 24.8 months for patients treated with abiraterone and olaparib versus 16.6 months for those receiving abiraterone alone.

MeSH terms

  • Androstenes
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Humans
  • Male
  • Phthalazines*
  • Piperazines*
  • Prostatic Neoplasms, Castration-Resistant* / drug therapy

Substances

  • abiraterone
  • olaparib
  • Androstenes
  • Phthalazines
  • Piperazines