Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors

Simai Zhang; Minlan Yuan; Danmei He; Wen Dang; Wei Zhang

doi:10.1007/s00406-023-01741-4

Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors

Eur Arch Psychiatry Clin Neurosci. 2024 Feb 6. doi: 10.1007/s00406-023-01741-4. Online ahead of print.

Authors

Simai Zhang^#^{1

2}, Minlan Yuan^#³, Danmei He⁴, Wen Dang⁴, Wei Zhang^{5

6

7}

Affiliations

¹ West China Biomedical Big Data Center, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu, 610041, China.
² Med-X Center for Informatics, Sichuan University, Chengdu, 610041, China.
³ Mental Health Center, West China Hospital, Sichuan University, Chengdu, 610041, China. minlanyuan@wchscu.cn.
⁴ Mental Health Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
⁵ West China Biomedical Big Data Center, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu, 610041, China. weizhanghx@163.com.
⁶ Med-X Center for Informatics, Sichuan University, Chengdu, 610041, China. weizhanghx@163.com.
⁷ Mental Health Center, West China Hospital, Sichuan University, Chengdu, 610041, China. weizhanghx@163.com.

^# Contributed equally.

PMID: 38319396
DOI: 10.1007/s00406-023-01741-4

Abstract

Objective: This study aimed to evaluate the neuropsychiatric symptoms of quarantined COVID-19 survivors 15 months after discharge and explore its potential association with structural and functional brain changes and inflammation.

Methods: A total of 51 quarantined COVID-19 survivors and 74 healthy controls were included in this study. Cognitive function was assessed using the THINC-integrated tool. Structural brain changes were examined through both surface- and volume-based analyses, and functional changes were assessed using resting-state amplitude low-frequency fluctuation (ALFF). Serum inflammatory markers were measured by a multiplexed flow cytometric assay.

Results: COVID-19 survivors exhibited subjective cognitive decline compared to healthy controls, despite no significant differences in objective cognitive tasks. Structural analysis revealed significantly increased gray matter volume and cortical surface area in the left transverse temporal gyrus (Heschl's gyrus) in quarantined COVID-19 survivors. This enlargement was negatively correlated with cognitive impairment. The ALFF analysis showed decreased neural activity in multiple brain regions. Elevated levels of serum inflammatory markers were also found in COVID-19 survivors, including MIP-1a, MIP-1b, TNF-a, and IL-8, which correlated with functional abnormalities.

Conclusions: Our findings indicate a subjective cognitive decline in quarantined COVID-19 survivors 15 months after discharge, which is associated with brain structural alterations in the left Heschl's gyrus. The observed elevation of inflammatory markers suggests a potential mechanism involving inflammation-induced neurogenesis. These results contribute to our understanding of the possible mechanisms underlying long-term neuropsychiatric consequences of COVID-19 and highlight the need for further research to develop targeted interventions.

Keywords: Cognitive impairment; Inflammation; Long covid; Neuroimaging; Neuropsychiatric sequela.

Abstract

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