Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease

Gopala K Rangan; Annette T Y Wong; Alexandra Munt; Jennifer Q J Zhang; Sayanthooran Saravanabavan; Sandra Louw; Margaret Allman-Farinelli; Sunil V Badve; Neil Boudville; Jessie Chan; Helen Coolican; Susan Coulshed; Marie E Edwards; Bradley J Erickson; Mangalee Fernando; Sheryl Foster; Adriana V Gregory; Imad Haloob; Carmel M Hawley; Jane Holt; Kirsten Howard; Martin Howell; David W Johnson; Timothy L Kline; Karthik Kumar; Vincent W Lee; Maureen Lonergan; Jun Mai; Philip McCloud; Elaine Pascoe; Anthony Peduto; Anna Rangan; Simon D Roger; Julie Sherfan; Kamal Sud; Vicente E Torres; Eswari Vilayur; David C H Harris

doi:10.1056/EVIDoa2100021

Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease

NEJM Evid. 2022 Jan;1(1):EVIDoa2100021. doi: 10.1056/EVIDoa2100021. Epub 2021 Nov 4.

Authors

Gopala K Rangan^{1

2

3}, Annette T Y Wong^{1

2}, Alexandra Munt^{1

2}, Jennifer Q J Zhang^{1

2}, Sayanthooran Saravanabavan^{1

2}, Sandra Louw⁴, Margaret Allman-Farinelli⁵, Sunil V Badve^{6

7}, Neil Boudville^{8

9}, Jessie Chan⁴, Helen Coolican¹⁰, Susan Coulshed¹¹, Marie E Edwards¹², Bradley J Erickson¹², Mangalee Fernando¹³, Sheryl Foster^{14

15}, Adriana V Gregory¹², Imad Haloob¹⁶, Carmel M Hawley^{17

18}, Jane Holt¹⁹, Kirsten Howard²⁰, Martin Howell²⁰, David W Johnson^{17

18}, Timothy L Kline¹², Karthik Kumar²¹, Vincent W Lee^{1

2

3

20

22}, Maureen Lonergan¹⁹, Jun Mai²³, Philip McCloud⁴, Elaine Pascoe¹⁷, Anthony Peduto¹⁴, Anna Rangan⁵, Simon D Roger²⁴, Julie Sherfan²⁵, Kamal Sud^{2

26

27}, Vicente E Torres¹², Eswari Vilayur²⁸, David C H Harris^{1

2

3}

Affiliations

¹ Michael Stern Laboratory for Polycystic Kidney Disease, Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia.
² Department of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Westmead, New South Wales, Australia.
³ Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia.
⁴ McCloud Consulting Group, Belrose, New South Wales, Australia.
⁵ Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney.
⁶ Department of Renal Medicine, St. George Hospital, Kogarah, New South Wales, Australia.
⁷ The George Institute for Global Health, University of New South Wales, Sydney.
⁸ Department of Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
⁹ Medical School, University of Western Australia, Perth, Western Australia, Australia.
¹⁰ PKD Australia, Roseville, New South Wales, Australia.
¹¹ North Shore Nephrology, Crows Nest, New South Wales, Australia.
¹² Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, MN.
¹³ Department of Renal Medicine, Prince of Wales Hospital, Eastern Sydney Health District Randwick, New South Wales, Australia.
¹⁴ Department of Radiology, Westmead Hospital, Western Sydney Local Health District, Westmead, New South Wales, Australia.
¹⁵ School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney.
¹⁶ Department of Renal Medicine, Bathurst Hospital, Bathurst, New South Wales, Australia.
¹⁷ Australasian Kidney Trials Network, University of Queensland at Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
¹⁸ Faculty of Medicine, Princess Alexandra Hospital Southside Clinical Unit, Brisbane, Queensland, Australia.
¹⁹ Department of Renal Medicine, Wollongong Hospital, Illawarra Shoalhaven Local Health District, Wollongong, New South Wales, Australia.
²⁰ School of Public Health, The University of Sydney, Sydney.
²¹ Gosford Nephrology, Gosford, New South Wales, Australia.
²² Department of Renal Medicine, Norwest Private Hospital, Bella Vista, New South Wales, Australia.
²³ Department of Renal Medicine, Liverpool Hospital, Southwestern Sydney Local Health District, Liverpool, New South Wales, Australia.
²⁴ Renal Research, Gosford, New South Wales, Australia.
²⁵ Chemical Pathology Department, Royal Prince Alfred Hospital, NSW Health Pathology, Sydney.
²⁶ Department of Renal Medicine, Nepean Hospital, Nepean Blue Mountains Local Health District, Sydney.
²⁷ Nepean Clinical School, The University of Sydney Medical School, Kingswood, New South Wales, Australia.
²⁸ Department of Nephrology, John Hunter Hospital, Newcastle, New South Wales, Australia.

PMID: 38319283
DOI: 10.1056/EVIDoa2100021

Abstract

Prescribed Water Intake in Autosomal Dominant Polycystic Kidney Disease The effect of increased water intake on kidney cyst growth in patients with polycystic kidney disease was compared for two groups randomly assigned to either prescribed or ad libitum water intake. Over 3 years, there was no difference in height-corrected total kidney volume between the groups.