Real-Time Artificial Intelligence-Based Optical Diagnosis of Neoplastic Polyps during Colonoscopy

Ishita Barua; Paulina Wieszczy; Shin-Ei Kudo; Masashi Misawa; Øyvind Holme; Shraddha Gulati; Sophie Williams; Kensaku Mori; Hayato Itoh; Kazumi Takishima; Kenichi Mochizuki; Yuki Miyata; Kentaro Mochida; Yoshika Akimoto; Takanori Kuroki; Yuriko Morita; Osamu Shiina; Shun Kato; Tetsuo Nemoto; Bu Hayee; Mehul Patel; Nishmi Gunasingam; Alexandra Kent; Andrew Emmanuel; Carl Munck; Jens Aksel Nilsen; Stine Astrup Hvattum; Svein Oskar Frigstad; Petter Tandberg; Magnus Løberg; Mette Kalager; Amyn Haji; Michael Bretthauer; Yuichi Mori

doi:10.1056/EVIDoa2200003

Real-Time Artificial Intelligence-Based Optical Diagnosis of Neoplastic Polyps during Colonoscopy

NEJM Evid. 2022 Jun;1(6):EVIDoa2200003. doi: 10.1056/EVIDoa2200003. Epub 2022 Apr 13.

Authors

Ishita Barua^{1

2}, Paulina Wieszczy^{1

2

3}, Shin-Ei Kudo⁴, Masashi Misawa⁴, Øyvind Holme^{1

2

5}, Shraddha Gulati⁶, Sophie Williams⁶, Kensaku Mori⁷, Hayato Itoh⁷, Kazumi Takishima⁴, Kenichi Mochizuki⁴, Yuki Miyata⁴, Kentaro Mochida⁴, Yoshika Akimoto⁴, Takanori Kuroki⁴, Yuriko Morita⁴, Osamu Shiina⁴, Shun Kato⁴, Tetsuo Nemoto⁸, Bu Hayee⁶, Mehul Patel⁶, Nishmi Gunasingam⁶, Alexandra Kent⁶, Andrew Emmanuel⁶, Carl Munck⁹, Jens Aksel Nilsen⁹, Stine Astrup Hvattum⁹, Svein Oskar Frigstad⁹, Petter Tandberg⁹, Magnus Løberg^{1

2}, Mette Kalager^{1

2}, Amyn Haji⁶, Michael Bretthauer^{1

2}, Yuichi Mori^{1

2

4}

Affiliations

¹ Clinical Effectiveness Research Group, University of Oslo, Oslo.
² Clinical Effectiveness Research Group, Department of Transplantation Medicine, Oslo University Hospital, Oslo.
³ Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland.
⁴ Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
⁵ Department of Medicine, Sørlandet Hospital Kristiansand, Kristiansand, Norway.
⁶ King's Institute of Therapeutic Endoscopy, King's College Hospital NHS Foundation Trust, London.
⁷ Graduate School of Informatics, Nagoya University, Nagoya, Japan.
⁸ Department of Diagnostic Pathology, School of Medicine, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
⁹ Department of Medicine, Baerum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.

PMID: 38319238
DOI: 10.1056/EVIDoa2200003

Abstract

Real-Time AI-Based Diagnosis of Neoplastic PolypsColonoscopists diagnosed small colonic polyps as benign or malignant on the basis of their appearance. The results were compared in real time to see if CADx could distinguish among polyps requiring removal. For standard visual inspection versus CADx, we determined sensitivity for diagnosis (88.4% vs. 90.4%) and high confidence in assessment (74.2% vs. 92.6%).