Potential Identification of Type 2 Diabetes with Elevated Insulin Clearance

Seigo Sugiyama; Hideaki Jinnouchi; Kunio Hieshima; Noboru Kurinami; Katsunori Jinnouchi; Akira Yoshida; Tomoko Suzuki; Keizo Kajiwara; Fumio Miyamoto; Tomio Jinnouchi

doi:10.1056/EVIDoa2100052

Potential Identification of Type 2 Diabetes with Elevated Insulin Clearance

NEJM Evid. 2022 Apr;1(4):EVIDoa2100052. doi: 10.1056/EVIDoa2100052. Epub 2022 Mar 15.

Authors

Seigo Sugiyama^{1

2}, Hideaki Jinnouchi^{1

2

3}, Kunio Hieshima^{1

4}, Noboru Kurinami^{1

5}, Katsunori Jinnouchi^{1

6}, Akira Yoshida^{1

7}, Tomoko Suzuki^{1

2}, Keizo Kajiwara^{1

2}, Fumio Miyamoto^{1

8}, Tomio Jinnouchi^{1

2}

Affiliations

¹ Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.
² Division of Cardiovascular Medicine, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.
³ Division of Preventive Cardiology, Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto, Japan.
⁴ Infectious Disease Division, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.
⁵ Obesity Treatment Division, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.
⁶ Division of Gastroenterology and Nephrology, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.
⁷ Pharmacology Division, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.
⁸ Ophthalmology Division, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan.

PMID: 38319210
DOI: 10.1056/EVIDoa2100052

Abstract

Elevated Insulin Clearance in Type 2 Diabetes MellitusT2DM in Western populations has been attributed to insulin resistance. Of 100 patients in a cohort from Japan with newly diagnosed T2DM, 44 had elevated insulin clearance, and they also had a lower BMI. These differences could not be explained by alterations in hepatic or renal function. These data have the potential to describe a novel T2DM endotype.