Narrowing of the Parent Artery Angle Is Associated With Intracranial Aneurysm Growth

Shinya Yamaguchi; Masato Osaki; Taisuke Kitamura; Mariya Hokazono; Kayo Wakisaka; Takako Maruyama; Chiharu Yasuda; Tesuro Sayama; Shuji Arakawa; Koji Yoshimoto

doi:10.7759/cureus.51677

Narrowing of the Parent Artery Angle Is Associated With Intracranial Aneurysm Growth

Cureus. 2024 Jan 4;16(1):e51677. doi: 10.7759/cureus.51677. eCollection 2024 Jan.

Affiliations

¹ Department of Neurosurgery, Steel Memorial Yawata Hospital, Kitakyushu, JPN.
² Department of Cerebrovascular Disease, Steel Memorial Yawata Hospital, Kitakyushu, JPN.
³ Department of Neurosurgery, Kyushu University, Fukuoka, JPN.

Abstract

Objective: Although risk factors for intracranial aneurysm growth have been reported, studies investigating the influence of the parent artery angle are limited. In this study, we examined the relationship between intracranial aneurysm growth and parent artery angle narrowing by analyzing long-term follow-up magnetic resonance angiography data.

Methods: We retrospectively reviewed data of patients with untreated aneurysms and those treated by simple coil embolization, who were followed up by magnetic resonance angiography for over 24 months at the Steel Memorial Yawata Hospital between August 2007 and March 2023. We investigated the relationship of aneurysm growth with parent artery angle narrowing, age, sex, follow-up duration, previous subarachnoid hemorrhage, hypertension, smoking, aneurysm location, aneurysm type, maximum size, and neck size.

Results: A total of 180 aneurysms of 162 patients (women, n=113; untreated, n=136) were included. The median age at aneurysm diagnosis was 71 (63.8-76) years and the median follow-up duration was 69 (45-120) months. Among the 180 aneurysms, 41 (untreated, n=30; treated by simple coil embolization, n=11) showed growth during the follow-up period, with a risk of 4.4%/patient-year. In the univariable analysis, the parent artery angles on the initial and last follow-up images and angle change were significantly associated with aneurysm growth. However, in the multivariable analysis, the association remained significant only for angle change (odds ratio, 2.21; 95% confidence interval, 1.42-3.45). The cutoff value of parent artery angle change for intracranial aneurysm growth was -3.4°.

Conclusion: Parent artery angle narrowing was significantly associated with intracranial aneurysm growth. This parameter may be useful for the monitoring of patients with unruptured intracranial aneurysms and may contribute to discerning the mechanism of intracranial aneurysm growth.

Keywords: intracranial aneurysm growth; long-term follow-up; magnetic resonance angiography (mra); parent artery angle narrowing; risk factors; unruptured cerebral aneurysm.