MDMX in Cancer: A Partner of p53 and a p53-Independent Effector

Wu Lin; Yuxiang Yan; Qingling Huang; Dali Zheng

doi:10.2147/BTT.S436629

MDMX in Cancer: A Partner of p53 and a p53-Independent Effector

Biologics. 2024 Jan 31:18:61-78. doi: 10.2147/BTT.S436629. eCollection 2024.

Authors

Wu Lin^#¹, Yuxiang Yan^#², Qingling Huang¹, Dali Zheng²

Affiliations

¹ Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, People's Republic of China.
² Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, People's Republic of China.

^# Contributed equally.

Abstract

The p53 tumor suppressor protein plays an important role in physiological and pathological processes. MDM2 and its homolog MDMX are the most important negative regulators of p53. Many studies have shown that MDMX promotes the growth of cancer cells by influencing the regulation of the downstream target gene of tumor suppressor p53. Studies have found that inhibiting the MDMX-p53 interaction can effectively restore the tumor suppressor activity of p53. MDMX has growth-promoting activities without p53 or in the presence of mutant p53. Therefore, it is extremely important to study the function of MDMX in tumorigenesis, progression and prognosis. This article mainly reviews the current research progress and mechanism on MDMX function, summarizes known MDMX inhibitors and provides new ideas for the development of more specific and effective MDMX inhibitors for cancer treatment.

Keywords: MDMX; P53; cancer; inhibitors.

Publication types

Review

Grants and funding

This study was supported by grants from the National Natural Science Foundation of China (82172911, 82173180), Fujian Provincial Health Technology Project (2020CXA049), the Scientific Research Foundation for Advanced Talents of Fujian Medical University (XRCZX2020028), and the Natural Science Foundation of Fujian province(2021J01668).