The value of luteinizing hormone basal values and sex hormone-binding globulin for early diagnosis of rapidly progressive central precocious puberty

Meiyu Zhang; Jun Sun; Ying Wang; Yanhui Wu; Xiaona Li; Rong Li; Yafei Fang; Hua Bai; Peiliang Luo; Yingdi Yuan

doi:10.3389/fendo.2023.1273170

The value of luteinizing hormone basal values and sex hormone-binding globulin for early diagnosis of rapidly progressive central precocious puberty

Front Endocrinol (Lausanne). 2024 Jan 22:14:1273170. doi: 10.3389/fendo.2023.1273170. eCollection 2023.

Authors

Meiyu Zhang^#¹, Jun Sun^#^{1

2}, Ying Wang³, Yanhui Wu¹, Xiaona Li^{1

2}, Rong Li^{1

2}, Yafei Fang^{1

2}, Hua Bai^{1

2}, Peiliang Luo^{1

2}, Yingdi Yuan^{1

2

3}

Affiliations

¹ Pediatric Endocrinology Department, The First People's Hospital of Lianyuangang, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China.
² Pediatric Endocrinology Department, Xuzhou Medical University Affiliated Hospital of Lianyungang, Lianyungang, China.
³ Pediatric Endocrinology Department, Postgraduate Training Base of Lianyungang First People's Hospital of Jinzhou Medical University, Liaoning, China.

^# Contributed equally.

Abstract

Objective: This study aimed to investigate the diagnostic value of luteinizing hormone (LH) basal values and sex hormone-binding globulin (SHBG) for rapidly progressive central precocious puberty (RP-CPP).

Methods: A total of 121 girls presenting with secondary sexual characteristics were selected from the Department of Pediatric Endocrinology, Lianyungang Clinical Medical College of Nanjing Medical University, from May 2021 to June 2023. The children were followed up for 6 months and were divided into three groups: RP-CPP group (n=40), slowly progressive central precocious puberty (SP-CPP) group (n=40), and premature thelarche (PT) group (n=41). The differences in LH basal values and SHBG among girls in the three groups were compared. ROC curves were drawn to analyze the value of LH basal values and SHBG in identifying RP-CPP.

Results: Significant differences were observed in age, height, predicted adult height (PAH), weight, body mass index (BMI), bone age (BA), BA-chronological age (CA), LH basal, LH peak, FSH basal, LH peak/FSH peak, estradiol (E2), testosterone, and SHBG levels between the RP-CPP group and the SP-CPP and PT groups (P < 0.05). The LH basal value in the RP-CPP group was higher than that in the SP-CPP group and the PT group, while SHBG levels were lower than in the latter two groups, and these differences were statistically significant (P < 0.05). When the LH basal value was ≥0.58 IU/L and SHBG was ≤58.79 nmol/L, the sensitivity for diagnosing RP-CPP was 77.5% and 67.5%, and the specificity was 66.7% and 74.1%.

Conclusion: Detection of basal LH and SHBG levels allows for early diagnosis of the progression of central precocious puberty.

Keywords: ROC curves; central precocious puberty; luteinizing hormone (LH); rapidly progressive central precocious puberty; sex hormone-binding globulin (SHBG).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Early Diagnosis
Female
Follicle Stimulating Hormone
Humans
Luteinizing Hormone*
Puberty, Precocious* / diagnosis
Sex Hormone-Binding Globulin

Substances

Follicle Stimulating Hormone
Luteinizing Hormone
Sex Hormone-Binding Globulin

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (81900772).