AI-designed RF pulses enable fast pulsing heteronuclear multiple quantum coherence NMR experiment at high and ultra-high magnetic fields

Manu Veliparambil Subrahmanian; Gianluigi Veglia

doi:10.1039/d3cc05370a

AI-designed RF pulses enable fast pulsing heteronuclear multiple quantum coherence NMR experiment at high and ultra-high magnetic fields

Chem Commun (Camb). 2024 Feb 20;60(16):2240-2243. doi: 10.1039/d3cc05370a.

Authors

Manu Veliparambil Subrahmanian^{1

2}, Gianluigi Veglia^{1

2}

Affiliations

¹ Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA.
² Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA. vegli001@umn.edu.

PMID: 38315748
DOI: 10.1039/d3cc05370a

Abstract

We present a new AI-optimized 2D heteronuclear multiple quantum coherence (RAPID-HMQC) pulse sequence for NMR spectroscopy. RAPID-HMQC is a longitudinal ¹H relaxation-optimized experiment with new AI-designed band-selective pulses to accelerate the analysis of organic compounds, metabolites, biopolymers, and real-time monitoring of dynamic processes at high- and ultra-high magnetic fields.