Chin Augmentation and Treatment of Chin Retrusion with a Flexible Hyaluronic Acid Filler in Asian Subjects: A Randomized, Controlled, Evaluator-Blinded Study

Yun Xie; Hongyi Zhao; Wenyu Wu; Jinhua Xu; Bi Li; Sufan Wu; Kevin Chen; Torun Bromée; Qingfeng Li

doi:10.1007/s00266-023-03812-2

Chin Augmentation and Treatment of Chin Retrusion with a Flexible Hyaluronic Acid Filler in Asian Subjects: A Randomized, Controlled, Evaluator-Blinded Study

Aesthetic Plast Surg. 2024 Mar;48(5):1030-1036. doi: 10.1007/s00266-023-03812-2. Epub 2024 Feb 5.

Authors

Yun Xie¹, Hongyi Zhao², Wenyu Wu³, Jinhua Xu³, Bi Li⁴, Sufan Wu⁵, Kevin Chen⁶, Torun Bromée⁷, Qingfeng Li⁸

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Beijing Hospital, Beijing, China.
³ Huashan Hospital, Fudan University, Shanghai, China.
⁴ Peking University Third Hospital, Beijing, China.
⁵ Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, China.
⁶ Galderma Trading Co, Shanghai, China.
⁷ Galderma, Uppsala, Sweden.
⁸ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. dr.liqingfeng@shsmu.edu.cn.

Abstract

Background: Aesthetic improvement of the chin is increasingly requested by patients, including those of Chinese origin.

Methods: A randomized, evaluator-blinded, no-treatment controlled study evaluated the effectiveness and safety of a flexible hyaluronic acid (HA) filler, Restylane^® Defyne^TM (HA_DEF), in the correction of chin retrusion in a Chinese adult population over 12 months after treatment. On Day 1, subjects were randomized 3:1 into two groups, HA_DEF or delayed-treatment controls, and those in the HA_DEF group were administered treatment. An optional touch-up treatment was administered 1 month after treatment to obtain optimal chin augmentation. The initially untreated control group was offered delayed-treatment after 6 months (including 1-month touch-up).

Results: HA_DEF was superior to no-treatment in improving chin retrusion according to the blinded evaluator at 6 months [Galderma Chin Retrusion Scale (GCRS) responder rate (≥ 1-point improvement from baseline) of 81% vs. 5% for untreated controls; p < 0.001, meeting the primary effectiveness objective. A majority of subjects maintained improvement at 12 months (61% in the HA_DEF group). All subjects reported satisfaction with results at 6 months after treatment with HA_DEF and aesthetic improvement rates per the global aesthetic improvement scale (GAIS) were high for 12 months following treatment, with an acceptable safety profile.

Conclusions: These results demonstrated HA_DEF to be effective and safe for the correction of mild-to-moderate chin retrusion in Chinese subjects, confirming findings previously observed in a western population.

Level of evidence i: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Trial registration: ClinicalTrials.gov NCT03597256.

Keywords: Aesthetic improvement; Asian; Chin retrusion; Filler; Hyaluronic acid; Randomized controlled trial.

Publication types

Randomized Controlled Trial

MeSH terms

Adult
Chin
Cosmetic Techniques*
Dermal Fillers* / adverse effects
East Asian People*
Humans
Hyaluronic Acid
Skin Aging
Treatment Outcome

Substances

Dermal Fillers
Hyaluronic Acid

Associated data

ClinicalTrials.gov/NCT03597256