Surprising magic of CD24 beyond cancer

He Wang; Peng Shi; Xinyu Shi; Yaqing Lv; Hongwei Xie; Hai Zhao

doi:10.3389/fimmu.2023.1334922

Surprising magic of CD24 beyond cancer

Front Immunol. 2024 Jan 19:14:1334922. doi: 10.3389/fimmu.2023.1334922. eCollection 2023.

Authors

He Wang¹, Peng Shi², Xinyu Shi³, Yaqing Lv⁴, Hongwei Xie¹, Hai Zhao¹

Affiliations

¹ Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
² Department of Emergency Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
³ Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, China.
⁴ Department of Outpatient, The Affiliated Hospital of Qingdao University, Qingdao, China.

Abstract

CD24 has emerged as a molecule of significant interest beyond the oncological arena. Recent studies have unveiled its surprising and diverse roles in various biological processes and diseases. This review encapsulates the expanding spectrum of CD24 functions, delving into its involvement in immune regulation, cancer immune microenvironment, and its potential as a therapeutic target in autoimmune diseases and beyond. The 'magic' of CD24, once solely attributed to cancer, now inspires a new paradigm in understanding its multifunctionality in human health and disease, offering exciting prospects for medical advancements.

Keywords: CD24; CD47; Covid-19; autoimmune diseases; innate checkpoint; metabolic diseases; neurological disease; non-neoplastic.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases* / therapy
CD24 Antigen
Humans
Neoplasms* / therapy
Tumor Microenvironment

Substances

CD24 Antigen
CD24 protein, human

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was funded by the Shandong Province Natural Science Foundation grants ZR2022QH372.