Synthesis and crystallographic characterization of 6-hydroxy-1,2-dihydropyridin-2-one

Sara K Phillips; Savannah G Brancato; Samantha N MacMillan; Mark J Snider; Andrew J Roering; Katherine A Hicks

doi:10.1107/S205698902300974X

Synthesis and crystallographic characterization of 6-hydroxy-1,2-dihydropyridin-2-one

Acta Crystallogr E Crystallogr Commun. 2023 Nov 14;79(Pt 12):1147-1150. doi: 10.1107/S205698902300974X. eCollection 2023 Dec 1.

Authors

Sara K Phillips¹, Savannah G Brancato¹, Samantha N MacMillan², Mark J Snider³, Andrew J Roering¹, Katherine A Hicks¹

Affiliations

¹ Department of Chemistry, The State University of New York at Cortland, Cortland, New York 13045, USA.
² Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
³ Department of Chemistry, The College of Wooster, Wooster, Ohio 44691, USA.

Abstract

The title compound, C₅H₅NO₂, is a hy-droxy-lated pyridine ring that has been studied for its involvement in microbial degradation of nicotinic acid. Here we describe its synthesis as a formic acid salt, rather than the standard hydro-chloride salt that is commercially available, and its spectroscopic and crystallographic characterization.

Keywords: crystal structure; hydrogen bonding; nicotinic acid derivative.

Grants and funding

Funding for this research was provided by: National Science Foundation (MCB 1817535 to MJS and 1817633 to KAH).