The role of ferroptosis in central nervous system damage diseases

PeerJ. 2024 Jan 30:12:e16741. doi: 10.7717/peerj.16741. eCollection 2024.

Abstract

Ferroptosis is a form of cell death, i.e., programmed cell death characterized by lipid peroxidation and iron dependence, which has unique morphological and biochemical properties. This unique mode of cell death is driven by iron-dependent phospholipid peroxidation and regulated by multiple cell metabolic pathways, including redox homeostasis, iron metabolism, mitochondrial activity, and the metabolism of amino acids, lipids, and sugars. Many organ injuries and degenerative pathologies are caused by ferroptosis. Ferroptosis is closely related to central nervous system injury diseases and is currently an important topic of research globally. This research examined the relationships between ferroptosis and the occurrence and treatment of central nervous system injury diseases. Additionally, ferroptosis was assessed from the aspect of theory proposal, mechanism of action, and related signaling pathways per recent research. This review provides a relevant theoretical basis for further research on this theory, the prospect of its development, and the prevention and treatment of such diseases.

Keywords: Ferroptosis; GPX4; Nerve damage; Redox.

Publication types

  • Review

MeSH terms

  • Amino Acids
  • Antifibrinolytic Agents*
  • Central Nervous System
  • Central Nervous System Diseases*
  • Ferroptosis*
  • Humans
  • Iron

Substances

  • Amino Acids
  • Antifibrinolytic Agents
  • Iron

Grants and funding

This research was supported by the China National Natural Science Foundation (82104838), the Liaoning Natural Science Foundation (2020-ZLLH-50), and the Liaoning Provincial Natural Science Foundation Doctor Program (2022-BS-059). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.