Protective effect of chitosan-modified rice porous starch loaded catechin on HT-29 cells exposed to lead ion

Suwei Jiang; Hailiang Hu

doi:10.1016/j.heliyon.2024.e25019

Protective effect of chitosan-modified rice porous starch loaded catechin on HT-29 cells exposed to lead ion

Heliyon. 2024 Jan 19;10(2):e25019. doi: 10.1016/j.heliyon.2024.e25019. eCollection 2024 Jan 30.

Authors

Suwei Jiang¹, Hailiang Hu²

Affiliations

¹ Suwei Jiang, School of Biological, Food and Environmental, Hefei University, Hefei, 230601, Anhui, China.
² Hailiang Hu, Department of Blood Transfusion, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.

Abstract

To explore how chitosan-modified rice porous starch-loaded catechin (CT@RPS/CS) protects HT-29 cells exposed to lead ions.

Method: The HT-29 cells were treated differently based on their grouping. The effect of CT@RPS/CS on lead-induced toxicity was evaluated using cell proliferation, apoptosis, oxidative stress index, and cytokine tests.

Results: CT@RPS/CS did not affect the activity, cell apoptosis, oxidative stress level, and related cytokines of HT-29 cells. After exposure to lead, CT@RPS/CS has the potential to enhance cellular activity, minimize apoptosis, and decrease the level of oxidative stress.

Discussion: CT@RPS/CS not only has no toxicity to cells but also adsorbs lead ions, which protects cells.

Keywords: Adsorber; Catechin; Chitosan; Lead ions; Porous starch.