Current status of yttrium-90 microspheres radioembolization in primary and metastatic liver cancer

Yasaman Anbari; Floortje E Veerman; Grace Keane; Arthur J A T Braat; Maarten L J Smits; Rutger C G Bruijnen; Wenle Tan; Ye Li; Feng Duan; Marnix G E H Lam

doi:10.1016/j.jimed.2023.09.001

Current status of yttrium-90 microspheres radioembolization in primary and metastatic liver cancer

J Interv Med. 2023 Sep 19;6(4):153-159. doi: 10.1016/j.jimed.2023.09.001. eCollection 2023 Nov.

Authors

Affiliations

¹ University Medical Center Utrecht, Utrecht, the Netherlands.
² Interventional Radiology Department, Chinese PLA General Hospital, Beijing, China.

Abstract

Liver malignancy, including primary liver cancer and metastatic liver cancer, has become one of the most common causes of cancer-related death worldwide due to the high malignant degree and limited systematic treatment strategy. Radioembolization with yttrium-90 (⁹⁰Y)-loaded microspheres is a relatively novel technology that has made significant progress in the local treatment of liver malignancy. The different steps in the extensive work-up of radioembolization for patients with an indication for treatment with ⁹⁰Y microspheres, from patient selection to follow up, both technically and clinically, are discussed in this paper. It describes the application and development of ⁹⁰Y microspheres in the treatment of liver cancer.

Keywords: Metastatic liver cancer; Primary liver cancer; Selective internal radiation therapy; Trans-arterial radioembolization; Yttrium-90 microspheres.