Constipation in hospitalized psychiatric patients: An underestimated common phenomenon. Retrospective epidemiological study in an adult psychiatric hospital setting

Valerie Dauriac-Le Masson; Cedric Bornes; Lisa Hadjedj; Philippe Montariol; Sylvie Nguyen-Machet; Nabil Hallouche

doi:10.1016/j.encep.2023.11.006

Constipation in hospitalized psychiatric patients: An underestimated common phenomenon. Retrospective epidemiological study in an adult psychiatric hospital setting

Encephale. 2024 Feb 3:S0013-7006(23)00213-0. doi: 10.1016/j.encep.2023.11.006. Online ahead of print.

Authors

Valerie Dauriac-Le Masson¹, Cedric Bornes², Lisa Hadjedj², Philippe Montariol², Sylvie Nguyen-Machet², Nabil Hallouche²

Affiliations

¹ Medical Information Departement, GHU-Paris psychiatrie et neurosciences, 1, rue Cabanis, 75014 Paris, France. Electronic address: v.lemasson@ghu-paris.fr.
² Physical Departement, GHU-Paris psychiatrie et neurosciences, 1, rue Cabanis, 75014 Paris, France.

PMID: 38311484
DOI: 10.1016/j.encep.2023.11.006

Abstract

Objective: Constipation is more common in patients with mental disorders than in the general population. However, its frequency in hospitalized patients, its association with drugs and how teams become aware of it and take care of it are not fully identified.

Method: The retrospective study included 141 male and 127 female new patients admitted for routine treatment at France's largest psychiatric hospital between November 15 and December 11, 2017. A physician reviewed electronic medical records to diagnose constipation and record variables of interest: socio-demographic factors, diagnosis, drugs prescribed and taken. We calculated an anticholinergic impregnation score (AIS) for each patient by using a validated French scale. Patients were then classified into two groups by state of constipation defined by the physician. Univariate and multivariate analyses were used to study the frequency of constipation, factors associated with it and its management.

Results: The prevalence of constipation was 38% (95% CI 32-44). Associated factors were taking antipsychotics and the burden of anticholinergic treatment. On multiple regression analysis, the only remaining factor was anticholinergic treatment: AIS≥5 was associated with constipation (odds ratio 1.80 [95% CI 1.07-3.14], P=0.027). Only 44.0% of patients were prescribed a preventive laxative, systematically in half of the cases. Above all, only 11.2% were administered this laxative (i.e., 25% of that prescribed). Digestive transit was poorly recorded in the table of constants (34.7%). We found one case of sub-occlusion as a severe case.

Conclusion: Constipation is common in psychiatric inpatients. The more the patient is prescribed drugs with a pronounced anticholinergic effect, the greater the risk. Alongside the preventive measures common to all psychiatric patients which must be promoted (concerning diet, physical activity, etc.), polymedication with this type of anticholinergic must be better monitored to prevent complications: prescription and administration of a preventive laxative, monitoring transit in the table of constants. Thus, a better knowledge of the subject and specific training are essential.

Keywords: Anticholinergic; Anticholinergique; Constipation; Gastrointestinal hypomotility; Hypomotilité gastro-intestinale; Maladie mentale; Mental health disease; Psychotropes; Psychotropics.