Radioprotection in the production of 18F-FDG at Brazilian cyclotron facilities: A comparative study based on dosimetry

Appl Radiat Isot. 2024 Apr:206:111189. doi: 10.1016/j.apradiso.2024.111189. Epub 2024 Jan 12.

Abstract

Since the end of the Brazilian state monopoly in 2006, allowing private enterprises to act in producing and commercializing short half-life radiopharmaceuticals, the country observed a growth in the laboratories that use 18F-FDG to PET/CT exams. Considering the radiological protection and safety techniques applied to radioisotope-producing facilities or units, this study assembled the current situation of radiological protection showing the received doses of the professionals of four facilities with cyclotrons for 18F-FDG located in south and southeast Brazil in the years 2020 and 2021. The dose values observed are below the dose limits established by national and international regulatory entities but can still be optimized considering differences between the production units.

Keywords: (18)F-FDG production; Cyclotron facility; Dosimetry; Occupational exposure; Radiological protection.

MeSH terms

  • Brazil
  • Cyclotrons
  • Fluorodeoxyglucose F18*
  • Positron Emission Tomography Computed Tomography* / methods
  • Radiopharmaceuticals

Substances

  • Fluorodeoxyglucose F18
  • Radiopharmaceuticals