miR-Blood - a small RNA atlas of human blood components

Julia Jehn; Franziska Trudzinski; Rastislav Horos; Judith Schenz; Florian Uhle; Markus A Weigand; Maurice Frank; Mustafa Kahraman; Marco Heuvelman; Tobias Sikosek; Timothy Rajakumar; Jennifer Gerwing; Jasmin Skottke; Alberto Daniel-Moreno; Christina Rudolf; Franziska Hinkfoth; Kaja Tikk; Petros Christopoulos; Laura V Klotz; Hauke Winter; Michael Kreuter; Bruno R Steinkraus

doi:10.1038/s41597-024-02976-z

miR-Blood - a small RNA atlas of human blood components

Sci Data. 2024 Feb 2;11(1):164. doi: 10.1038/s41597-024-02976-z.

Authors

Julia Jehn^#¹, Franziska Trudzinski^#², Rastislav Horos¹, Judith Schenz³, Florian Uhle³, Markus A Weigand³, Maurice Frank¹, Mustafa Kahraman¹, Marco Heuvelman¹, Tobias Sikosek¹, Timothy Rajakumar¹, Jennifer Gerwing¹, Jasmin Skottke¹, Alberto Daniel-Moreno¹, Christina Rudolf¹, Franziska Hinkfoth¹, Kaja Tikk¹, Petros Christopoulos⁴, Laura V Klotz⁵, Hauke Winter⁵, Michael Kreuter², Bruno R Steinkraus⁶

Affiliations

¹ Hummingbird Diagnostics GmbH, Im Neuenheimer Feld 583, 69120, Heidelberg, Germany.
² Center for Interstitial and Rare Lung Diseases, Thoraxklinik, University of Heidelberg, and German Center for Lung Research (DZL), Heidelberg, Germany.
³ Department of Anesthesiology, Medical Faculty, Heidelberg University, Heidelberg, Germany.
⁴ Department of Thoracic Oncology, Thoraxklinik, University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), and German Center for Lung Research (DZL), Heidelberg, Germany.
⁵ Department of Thoracic Surgery, Thoraxklinik, University of Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), and German Center for Lung Research (DZL), Heidelberg, Germany.
⁶ Hummingbird Diagnostics GmbH, Im Neuenheimer Feld 583, 69120, Heidelberg, Germany. bsteinkraus@hb-dx.com.

^# Contributed equally.

Abstract

miR-Blood is a high-quality, small RNA expression atlas for the major components of human peripheral blood (plasma, erythrocytes, thrombocytes, monocytes, neutrophils, eosinophils, basophils, natural killer cells, CD4+ T cells, CD8+ T cells, and B cells). Based on the purified blood components from 52 individuals, the dataset provides a comprehensive repository for the expression of 4971 small RNAs from eight non-coding RNA classes.

Publication types

Dataset

MeSH terms

Eosinophils
Erythrocytes
Humans
MicroRNAs* / blood
Monocytes
Neutrophils / metabolism

Substances

MicroRNAs