ICTV Virus Taxonomy Profile: Filoviridae 2024

Nadine Biedenkopf; Alexander Bukreyev; Kartik Chandran; Nicholas Di Paola; Pierre B H Formenty; Anthony Griffiths; Adam J Hume; Elke Mühlberger; Sergey V Netesov; Gustavo Palacios; Janusz T Pawęska; Sophie Smither; Ayato Takada; Victoria Wahl; Jens H Kuhn

doi:10.1099/jgv.0.001955

ICTV Virus Taxonomy Profile: Filoviridae 2024

J Gen Virol. 2024 Feb;105(2). doi: 10.1099/jgv.0.001955.

Authors

Affiliations

¹ Philipps-University Marburg, Marburg, Germany.
² The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
³ Albert Einstein College of Medicine, New York, USA.
⁴ United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
⁵ World Health Organization, Geneva, Switzerland.
⁶ Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, USA.
⁷ Novosibirsk State University, Novosibirsk, Russia.
⁸ Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁹ National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham-Johannesburg, Gauteng, South Africa.
¹⁰ Dstl, Porton Down, Wiltshire, UK.
¹¹ International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
¹² National Biodefense Analysis and Countermeasures Center, Fort Detrick, Frederick, MD, USA.
¹³ Integrated Research Facility at Fort Detrick, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA.

PMID: 38305775
DOI: 10.1099/jgv.0.001955

Abstract

Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1-20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP_1,2), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae, which is available at www.ictv.global/report/filoviridae.

Keywords: Ebola; Filoviridae; ICTV Report; Marburg virus; filovirid; filovirus; orthoebolavirus; orthomarburgvirus; taxonomy.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ebolavirus* / genetics
Genome, Viral
Humans
Mammals / genetics
Marburgvirus*
Phylogeny
Rhabdoviridae* / genetics
Virus Replication

Grants and funding

001/WHO_/World Health Organization/International