Cu-Co Bimetallic Catalyst-based Electrochemical Sensing Platform for Determination of Bisoprolol in Clinical Samples

Mohammad Reza Salemi; Shahla Fathi; Fereshteh Chekin; Banafsheh Norouzi

doi:10.2174/0113862073270729231106090749

Cu-Co Bimetallic Catalyst-based Electrochemical Sensing Platform for Determination of Bisoprolol in Clinical Samples

Comb Chem High Throughput Screen. 2024 Jan 16. doi: 10.2174/0113862073270729231106090749. Online ahead of print.

Authors

Mohammad Reza Salemi¹, Shahla Fathi¹, Fereshteh Chekin¹, Banafsheh Norouzi²

Affiliations

¹ Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
² Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.

PMID: 38305403
DOI: 10.2174/0113862073270729231106090749

Abstract

Background: Bisoprolol (BIS) is a selective beta-blocker. It has been successfully used to treat hypertension and angina pectoris. An overdose of BIS can lead to serious complications. An overdose is a medical emergency that requires immediate medical attention to overcome the adverse effects of the overdose. Hence, sensitive, reliable, and cost-effective methods are required for the determination of BIS.

Methods: In this work, a new electrochemical sensing platform based on a bimetallic catalyst was developed for the determination of BIS. The Cu-Co nanocatalyst was easily synthesized by galvanic displacement onto a carbon paste electrode (CPE). Then, field emission scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS), and cyclic voltammetry (CV) were utilized for the characterization of the Cu-Co catalyst.

Results: The galvanic displacement of Cu metal significantly affected the electro-catalytic behavior of the Cu-Co catalyst and the Cu-Co/CPE electrode displayed a very sensitive and accurate response towards BIS. Under optimized conditions, the response was linear in the 3 to 120 μM concentration range, sensitivity of 631.1 μA mM-1 and a detection limit of as low as 0.4 μM using cyclic voltammetry. The simple proposed method was also successfully employed in the analysis of BIS in biological and pharmaceutical samples. The advantages of Cu-Co/CPE are its fast and simple manufacturing and the possibility of a repeated surface regeneration of the sensing platform, as well as its application for the detection of BIS in tablets and biological samples, making Cu-Co significant promise for use in clinical diagnostics. Besides, the synthesized catalysts showed excellent reusability and stability.

Conclusion: The presence of Cu metal due to galvanic displacement increased the sensitivity. These findings suggest that the new nanocatalyst has potential applications in sensors and electronics.

Keywords: Bisoprolol; bimetallic nanocatalyst; electrochemical sensor; galvanic displacement.