A Review on the Role of Inflammation in Coronavirus Disease

Arezoo Lotfi; Pouran Hajian; Laleh Abbasi; Morad Kohandel Gargari; Najmeh Nameh Goshay Fard; Delaram Naderi

doi:10.2174/0118715303265274231204075802

A Review on the Role of Inflammation in Coronavirus Disease

Endocr Metab Immune Disord Drug Targets. 2024 Feb 1. doi: 10.2174/0118715303265274231204075802. Online ahead of print.

Authors

Arezoo Lotfi¹, Pouran Hajian², Laleh Abbasi³, Morad Kohandel Gargari⁴, Najmeh Nameh Goshay Fard⁵, Delaram Naderi⁶

Affiliations

¹ Azerbaijan Medical University, Baku, Azerbaijan.
² Department of Anesthesiology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
³ Guilan University of Medical Sciences, Rasht, Iran.
⁴ Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranUniversity of Medical Sciences, Ahvaz, Iran ahwaz Iran.
⁶ Student Research Committee, Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.

PMID: 38303532
DOI: 10.2174/0118715303265274231204075802

Abstract

The respiratory illness known as COVID-19 is caused by the novel coronavirus, SARS-CoV-2. While the precise pathogenic mechanism of COVID-19 remains unclear, the occurrence of a cytokine storm subsequent to viral infection plays a pivotal role in the initiation and advancement of the disease. The infection of SARS-CoV-2 induces a state of immune system hyperactivity, leading to an excessive production of inflammatory cytokines. Consequently, the identification of the various signaling pathways implicated in the inflammation induced by COVID-19 will enable researchers to investigate new targets for therapeutic intervention.

Keywords: COVID-19; Coronavirus disease; Cytokine storm; Immune response; Inflammation; body immune system.