Two new compounds from biotransformation of glycyrrhetinic acid

Zehao Xie; Xinxin Gu; Aman Dekebo; Shaozhong Wei; Xuebo Hu

doi:10.1080/14786419.2024.2306918

Two new compounds from biotransformation of glycyrrhetinic acid

Nat Prod Res. 2024 Feb 1:1-5. doi: 10.1080/14786419.2024.2306918. Online ahead of print.

Authors

Zehao Xie¹, Xinxin Gu¹, Aman Dekebo², Shaozhong Wei³, Xuebo Hu¹

Affiliations

¹ Institute for Medicinal Plants, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China, Innovation Academy of International Traditional Chinese Medicinal Materials, Huazhong Agricultural University, Wuhan, China, National-Regional Joint Engineering Research Center in Hubei for Medicinal Plant Breeding and Cultivation, Huazhong Agricultural University, Wuhan, China, Medicinal Plant Engineering Research Center of Hubei Province, Huazhong Agricultural University, Wuhan, China.
² Applied Chemistry Department, School of Applied Natural Sciences, Adama Science and Technology University, Adama, Ethiopia, Institute of Pharmaceutical Sciences, Adama Science and Technology University, Adama, Ethiopia.
³ Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Colorectal cancer clinical research center of Hubei Province, Colorectal Cancer Clinical Research Center of Wuhan, China.

PMID: 38303502
DOI: 10.1080/14786419.2024.2306918

Abstract

Glycyrrhetinic acid may undergo biotransformation to obtain derivatives with stronger pharmacological activity and fewer side effects. This study used 19 fungi to biotransform glycyrrhetinic acid and yielded two compounds namely bicyclo(14.15.27)glycyrrhetinic acid (1) and 2-ene-glycyrrhetinic acid (2) from the glycyrrhetinic acid metabolites of two fungi, Botrytis cinerea B05.10 ATCC 11542 and Aspergillus ochraceopetaliformis ATCC 12066. Compound 1 inhibited HMEC-1 cell proliferation in a concentration-dependent manner (IC₅₀=239.1 µ M), but showed no significant cytotoxicity to A549 cells.

Keywords: 2-ene-glycyrrhetinic acid; Glycyrrhetinic acid; bicyclo(14.15.27)glycyrrhetinic; biotransformation; cytotoxicity; fungi.