Bisphenol S, bisphenol F, bisphenol a exposure and body composition in US adults

Buyun Liu; Yuxiang Yan; Juan Xie; Jian Sun; Hans-Joachim Lehmler; Leonardo Trasande; Robert B Wallace; Wei Bao

doi:10.1016/j.chemosphere.2023.140537

Bisphenol S, bisphenol F, bisphenol a exposure and body composition in US adults

Chemosphere. 2024 Jan:346:140537. doi: 10.1016/j.chemosphere.2023.140537. Epub 2023 Oct 28.

Authors

Buyun Liu¹, Yuxiang Yan², Juan Xie², Jian Sun³, Hans-Joachim Lehmler⁴, Leonardo Trasande⁵, Robert B Wallace⁶, Wei Bao²

Affiliations

¹ Institute of Public Health Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, China. Electronic address: liubuyunbubu@163.com.
² Institute of Public Health Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, China.
³ School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
⁴ Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, USA.
⁵ Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA; Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA.
⁶ Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.

PMID: 38303380
DOI: 10.1016/j.chemosphere.2023.140537

Abstract

Bisphenol S (BPS) and bisphenol F (BPF) are increasingly used to replace bisphenol A (BPA), an endocrine-disrupting chemical with putative obesogenic properties; whether and how BPS and BPF affect adiposity in humans remains to be determined. Therefore, we examined the association of BPA, BPS， and BPF with body composition among US adults. We included 1787 participants aged 20-59 years old in the National Health and Nutrition Examination Survey 2013-2016 who had information on urinary BPA, BPS, and BPF concentrations, and body composition measured using dual-energy x-ray absorptiometry. After full adjustment for potential confounders in linear regression models, BPA was significantly associated with the % body fat of the whole body, arm, and leg, with the β (95% CI) for the highest quartile vs. the lowest quartile of 1.34 (95%CI [0.11, 2.58], P = 0.03), 1.60 (95%CI [0.20, 3.00], P = 0.03), and 1.63 (95%CI [0.24, 3.02], P = 0.02), respectively. No association between BPA and lean mass was found. For BPS, significant associations were found for % body fat of the whole body (β [95% CI] = 1.42 [0.49, 2.36], P = 0.004), trunk (β[95% CI] = 1.92 [0.86, 2.97], P = 0.001), and arm (β [95% CI] = 1.60 [0.49, 2.70], P = 0.01), as well as lean mass of the whole body (β [95% CI] = 2610.6 [1324.3, 3896.8], P < 0.001), trunk (β [95% CI] = 1467.0 [745.3, 2188.7], P < 0.001), arm (β [95% CI] = 113.4 [10.3, 216.5], P = 0.03), and leg (β [95% CI] = 431.5 [219.6, 643.4], P < 0.001), comparing the third quartile vs. the lowest quartile. No significant association was observed between BPF and % body fat and lean mass. Results suggest that higher BPA levels were significantly associated with greater % body fat of the whole body and limbs, and there was suggestive evidence that BPS levels were associated with both % body fat and lean mass of the whole body and body parts in a nonmonotonic relationship.

Keywords: Bisphenol A; Bisphenol A substitute; Bisphenol F; Bisphenol S; Body composition; Fat mass; Lean mass.

MeSH terms

Adult
Benzhydryl Compounds*
Body Composition
Humans
Middle Aged
Nutrition Surveys
Phenols*
Sulfones*
Young Adult

Substances

bisphenol F
bisphenol A
Phenols
Benzhydryl Compounds
bis(4-hydroxyphenyl)sulfone
Sulfones