Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058

So-Ichiro Kimura; Yoshihiro Watanabe; Yudai Mikasa; Rei Miyano; Toshiyuki Tokiwa; Kenichi Nonaka; Takuji Nakashima; Yoshihiko Noguchi; Tomoyasu Hirose; Toshiaki Sunazuka; Rei Hokari; Aki Ishiyama; Masato Iwatsuki

doi:10.1038/s41429-023-00699-8

Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058

J Antibiot (Tokyo). 2024 Apr;77(4):206-213. doi: 10.1038/s41429-023-00699-8. Epub 2024 Feb 2.

Authors

So-Ichiro Kimura^#¹, Yoshihiro Watanabe^#^{1

2}, Yudai Mikasa³, Rei Miyano¹, Toshiyuki Tokiwa², Kenichi Nonaka^{1

2}, Takuji Nakashima², Yoshihiko Noguchi^{1

2}, Tomoyasu Hirose^{1

2}, Toshiaki Sunazuka^{1

2}, Rei Hokari^{1

2}, Aki Ishiyama^{1

2}, Masato Iwatsuki^{4

5}

Affiliations

¹ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
² Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
³ School of Science, Kitasato University, 1-15-1, Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
⁴ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.
⁵ Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.

^# Contributed equally.

PMID: 38302743
DOI: 10.1038/s41429-023-00699-8

Abstract

Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials*
Epoxy Compounds
Lactams*

Substances

pramanicin
Lactams
Epoxy Compounds
Antimalarials

Abstract

Publication types

MeSH terms

Substances

Grants and funding