Introduction: Currently, futile reperfusion (FR) is becoming a major challenge in the endovascular treatment of patients with acute ischemic stroke (AIS). The relationship between serum uric acid (SUA) and FR has not been investigated. This study aims to determine the relationship between SUA and FR using propensity score matching (PSM) analysis.
Methods: A total of 441 patients with AIS undergoing mechanical thrombectomy (MT) between August 2017 and January 2023 were included and divided into two groups based on the median SUA (297.4 μmol/L). Two groups were balanced using PSM analysis at a 1:1 ratio. The standardized mean difference (SMD) were used to assess the efficacy of the matching. Finally, 158 patients with low SUA (≤ 297.4 μmol/L) were matched with 158 patients with high SUA (>297.4 μmol/L). Predictors of FR were analyzed by multivariate logistic regression analysis in the PSM cohort.
Results: After PSM, patients with low SUA (≤ 297.4 μmol/L) had a significant higher incidence of FR (72.8 %, 115/158) than patients with high SUA (>297.4 μmol/L) (48.1 %, 76/158) (P<0.001). Multivariate logistic regression analysis in the PSM cohort showed that low SUA (≤ 297.4 μmol/L) was an independent risk factor for the efficacy of reperfusion (OR: 6.403, 95 % CI: 3.123-13.129, P<0.001), suggesting that patients with SUA ≤ 297.4 μmol/L have a 6.403 times higher risk of FR than patients with SUA>297.4 μmol/L.
Conclusion: The results of this study suggest that low SUA (≤ 297.4 μmol/L) at admission increases the risk of FR in AIS patients undergoing MT by PSM analysis.
Keywords: Acute ischemic stroke; Futile reperfusion; Mechanical thrombectomy; Oxidative stress; Uric acid.
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