Encapsulation of apigenin into β-cyclodextrin metal-organic frameworks with high embedment efficiency and stability

Yaqi Liu; Chao Yuan; Bo Cui; Meng Zhao; Bin Yu; Li Guo; Pengfei Liu; Yishan Fang

doi:10.1016/j.foodchem.2024.138543

Encapsulation of apigenin into β-cyclodextrin metal-organic frameworks with high embedment efficiency and stability

Food Chem. 2024 Jun 15:443:138543. doi: 10.1016/j.foodchem.2024.138543. Epub 2024 Jan 26.

Authors

Yaqi Liu¹, Chao Yuan², Bo Cui³, Meng Zhao¹, Bin Yu¹, Li Guo¹, Pengfei Liu¹, Yishan Fang¹

Affiliations

¹ State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China; School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
² State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China; School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China. Electronic address: yuanchao@qlu.edu.cn.
³ State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China; School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China. Electronic address: cuiborr@163.com.

PMID: 38301553
DOI: 10.1016/j.foodchem.2024.138543

Abstract

In an effort to improve the application performance of apigenin, β-cyclodextrin metal-organic frameworks (BCDMOFs) known as porous materials were used to encapsulate apigenin via an innovative pH-adjusted method. The embedment efficiency had a significant positive pH dependence, reaching a maximum of 79.2 % ± 1.2 % at pH12. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis demonstrated formation of apigenin/BCDMOFs composites, and exposure of BCDMOFs pores facilitated high embedment efficiency. Storage stability experiment and kinetic analysis showed degradation of apigenin/BCDMOFs composites was less than that of apigenin alone. Apigenin stability was increased by approximately 18 % after 7 days. BCDMOFs effectively encapsulated and controlled the release of apigenin, and the composites exhibited improved application performance in vitro.

Keywords: Apigenin; Composites; Decomposition kinetic; Microstructure; β-Cyclodextrin metal-organic frameworks.

MeSH terms

Apigenin
Kinetics
Metal-Organic Frameworks* / chemistry
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
beta-Cyclodextrins* / chemistry

Substances

Metal-Organic Frameworks
Apigenin
beta-Cyclodextrins